(Q39523252)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23137150%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

Current challenges and controversies in drug-induced liver injury (English)

1 reference

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17 February 2020

1

1 reference

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17 February 2020

author name string

Patricia Ganey

2

1 reference

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17 February 2020

Cynthia Ju

3

1 reference

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17 February 2020

Neil Kaplowitz

4

1 reference

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17 February 2020

Dominique Pessayre

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23137150%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Robert Roth

6

1 reference

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17 February 2020

Paul B Watkins

7

1 reference

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17 February 2020

Mudher Albassam

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23137150%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Baolian Liu

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23137150%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Saray Stancic

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23137150%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Laura Suter

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23137150%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Michele Bortolini

12

1 reference

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17 February 2020

publication date

1 December 2012

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17 February 2020

1 reference

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17 February 2020

volume

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23137150%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

issue

12

1 reference

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17 February 2020

page(s)

1099-1117

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23137150%20AND%20SRC:MED&resulttype=core&format=json

Current concepts of mechanisms in drug-induced hepatotoxicity

17 February 2020

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Idiosyncratic drug hepatotoxicity

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Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: search for signals

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Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events

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Potentiation of isoniazid-induced liver toxicity by rifampicin in a combinational therapy of antitubercular drugs (rifampicin, isoniazid and pyrazinamide) in Wistar rats: A toxicity profile study.

21 January 2018

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Halothane-induced liver injury in outbred guinea pigs: role of trifluoroacetylated protein adducts in animal susceptibility

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Late dimethyl sulfoxide administration provides a protective action against chemically induced injury in both the liver and the kidney.

21 January 2018

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Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection

21 January 2018

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Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity.

21 January 2018

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Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2(+/-) mice: two-stage oxidative injury

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Nimesulide-induced hepatic mitochondrial injury in heterozygous Sod2(+/-) mice

21 January 2018

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Induction of a hepatic toxic syndrome in the Dutch-belted rabbit by a quinoxalinone anxiolytic.

21 January 2018

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Toxicity of valproic acid in mice with decreased plasma and tissue carnitine stores

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Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy?

21 January 2018

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Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils

21 January 2018

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Sulindac metabolism and synergy with tumor necrosis factor-alpha in a drug-inflammation interaction model of idiosyncratic liver injury.

21 January 2018

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Hepatotoxic interaction of sulindac with lipopolysaccharide: role of the hemostatic system

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Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha

21 January 2018

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Effect of polyI:C cotreatment on halothane-induced liver injury in mice

21 January 2018

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Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha.

21 January 2018

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The role of the hemostatic system in murine liver injury induced by coexposure to lipopolysaccharide and trovafloxacin, a drug with idiosyncratic liability

21 January 2018

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Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity

21 January 2018

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Trovafloxacin enhances the inflammatory response to a Gram-negative or a Gram-positive bacterial stimulus, resulting in neutrophil-dependent liver injury in mice

21 January 2018

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Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury

21 January 2018

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Tumor necrosis factor alpha is a proximal mediator of synergistic hepatotoxicity from trovafloxacin/lipopolysaccharide coexposure

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A mouse model of severe halothane hepatitis based on human risk factors

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Role of neutrophils in a mouse model of halothane-induced liver injury

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Animal models of idiosyncratic drug reactions.

21 January 2018

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The current status of attempts to predict species differences in drug metabolism

21 January 2018

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Species differences in peroxisome proliferation; mechanisms and relevance.

21 January 2018

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Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species

21 January 2018

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Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

21 January 2018

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Dexamethasone metabolism in vitro: species differences

21 January 2018

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Role of gene knockout and transgenic mice in the study of xenobiotic metabolism

21 January 2018

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The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity

21 January 2018

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Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment

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Mice as clinically relevant models for the study of cytochrome P450-dependent metabolism

21 January 2018

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Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

21 January 2018

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Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver

21 January 2018

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The mitochondrial superoxide/thioredoxin-2/Ask1 signaling pathway is critically involved in troglitazone-induced cell injury to human hepatocytes

21 January 2018

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Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a review

21 January 2018

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Aromatic antiepileptic drugs and mitochondrial toxicity: effects on mitochondria isolated from rat liver

21 January 2018

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Mitochondrial permeability transition as a source of superoxide anion induced by the nitroaromatic drug nimesulide in vitro

21 January 2018

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Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor

21 January 2018

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Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models

21 January 2018

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Idiosyncratic drug-induced liver injury and the role of inflammatory stress with an emphasis on an animal model of trovafloxacin hepatotoxicity

21 January 2018

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Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.

21 January 2018

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A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation

21 January 2018

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Drug-Induced Liver Disease

21 January 2018

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Criteria of drug-induced liver disorders. Report of an international consensus meeting

21 January 2018

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Idiosyncratic liver injury: challenges and approaches.

21 January 2018

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Monitoring liver safety in drug development: the GSK experience.

21 January 2018

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AGA technical review on the evaluation of liver chemistry tests

21 January 2018

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Impact of biomarker development on drug safety assessment

21 January 2018

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Enhancing the utility of alanine aminotransferase as a reference standard biomarker for drug-induced liver injury

21 January 2018

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Mechanism-based bioanalysis and biomarkers for hepatic chemical stress.

21 January 2018

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Alpha-glutathione S-transferase in the assessment of hepatotoxicity--its diagnostic utility in comparison with other recognized markers in the Wistar Han rat.

21 January 2018

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Distribution of glutathione S-transferase isoenzymes in human kidney: basis for possible markers of renal injury

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03261997

Structural, Functional, and Clinical Aspects of γ-Glutamyltransferase

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03261997

Serum gamma-glutamyl transpeptidase activity in patients receiving chronic phenytoin therapy

21 January 2018

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Normal Ranges and Diagnostic Value of Serum 5'Nucleotidase and Alkaline Phosphatase Activities in Infancy

21 January 2018

1 reference

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Studies on alkaline phosphatase isoenzymes. relation to γ-glutamyltransferase and lactate dehydrogenase isoenzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Hyperbilirubinemia and cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Measurement of serum paraoxonase-1 activity in the evaluation of liver function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Immunohistochemical evidence for the expression and induction of paraoxonase in rat liver, kidney, lung and brain tissue. Implications for its physiological role

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03261997

The current state of serum biomarkers of hepatotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Induction of neutrophil gelatinase-associated lipocalin in vascular injury via activation of nuclear factor-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Identification of neutrophil gelatinase-associated lipocalin (NGAL) as a discriminatory marker of the hepatocyte-secreted protein response to IL-1beta: a proteomic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Urinary clusterin, cystatin C, beta2-microglobulin and total protein as markers to detect drug-induced kidney injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Clusterin: Physiologic and pathophysiologic considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Interlaboratory evaluation of genomic signatures for predicting carcinogenicity in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Circulating microRNAs, potential biomarkers for drug-induced liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Circulating microRNAs, possible indicators of progress of rat hepatocarcinogenesis from early stages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

A prospective study of acute drug-induced liver injury in patients suffering from non-alcoholic fatty liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Review article: The use of potentially hepatotoxic drugs in patients with liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Drug-induced liver injury associated with the use of nonnucleoside reverse-transcriptase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Highly active antiretroviral therapy-induced liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Antiretroviral-associated liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Incidence of and risk factors for severe hepatotoxicity associated with antiretroviral combination therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

A problem-oriented approach to liver disease in oncology patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Cancer chemotherapy I: hepatocellular injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

The existence of a relationship between increased serum alanine aminotransferase levels detected in premarketing clinical trials and postmarketing published hepatotoxicity case reports.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Evaluation of drug-induced serious hepatotoxicity (eDISH): application of this data organization approach to phase III clinical trials of rivaroxaban after total hip or knee replacement surgery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03261997

Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities

21 January 2018

1 reference

12 December 2020

Circulating levels of cytochrome C, gamma-glutamyl transferase, triglycerides and unconjugated bilirubin in overweight/obese patients with non-alcoholic fatty liver disease

1 reference

12 December 2020

Hepatic dysfunction associated with troglitazone

1 reference

12 December 2020

Safety of newly approved drugs: implications for prescribing

1 reference

12 December 2020

Subanesthetic halothane is hepatotoxic in the guinea pig

1 reference

12 December 2020

Impaired bile flow and disordered hepatic calcium homeostasis are early features of halothane-induced liver injury in guinea pigs.

1 reference

12 December 2020

Serum paraoxonase activity: a new additional test for the improved evaluation of chronic liver damage.

1 reference

12 December 2020

Hepatotoxicity of chemotherapeutic and oncologic agents

1 reference

12 December 2020

Generation of humanized animal livers using embryoid body-derived stem cell transplant

1 reference

12 December 2020

The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse.

1 reference

12 December 2020

Peginterferon alfa-2b plus ribavirin for treatment of chronic hepatitis C in previously untreated patients infected with HCV genotypes 2 or 3.

1 reference

12 December 2020

An assessment of 5'-nucleotidase as a liver-function test

1 reference

12 December 2020

Hepatotoxicity of antiretrovirals: incidence, mechanisms and management

1 reference

12 December 2020

Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice

1 reference

12 December 2020

Diet Restriction Inhibits Apoptosis and HMGB1 Oxidation and Promotes Inflammatory Cell Recruitment during Acetaminophen Hepatotoxicity

1 reference

12 December 2020

Review of pyridoxal phosphate and the transaminases in liver disease.

1 reference

12 December 2020

Modeling inflammation-drug interactions in vitro: a rat Kupffer cell-hepatocyte coculture system

1 reference

12 December 2020

Serum malate dehydrogenase (MDH) in portal hypertension--its value as a diagnostic and prognostic indicator

1 reference

12 December 2020

Glutathione depletion enhances subanesthetic halothane hepatotoxicity in guinea pigs

1 reference

12 December 2020

Assessment of candidate biomarkers of drug-induced hepatobiliary injury in preclinical toxicity studies

1 reference

12 December 2020

Role of CYP2E1 in the hepatotoxicity of acetaminophen

1 reference

12 December 2020

SORBITOL DEHYDROGENASE IN THE DIAGNOSIS OF LIVER DISEASE

1 reference

12 December 2020

Hy's law: predicting serious hepatotoxicity

1 reference

12 December 2020

Acute hepatotoxicity: a predictive model based on focused illumina microarrays

1 reference

12 December 2020

Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation

1 reference

12 December 2020

Serum gamma-glutamyl transpeptidase activity as an indicator of disease of liver, pancreas, or bone.

1 reference

12 December 2020

"Gene-swap knock-in" cassette in mice to study allelic differences in human genes.

1 reference

12 December 2020

Serum glutamic pyruvic transaminase in cardiac with hepatic disease

1 reference

12 December 2020

Deranged blood coagulation equilibrium as a factor of massive liver necrosis following endotoxin administration in partially hepatectomized rats

1 reference

12 December 2020

LIVER DISEASE, HEPATIC ALCOHOL DEHYDROGENASE ACTIVITY, AND ALCOHOL METABOLISM IN THE HUMAN

1 reference

12 December 2020

The clinical significance of transaminase activities of serum

1 reference

12 December 2020

Serum alkaline phosphatase and 5'-nucleotidase levels during normal pregnancy

1 reference

12 December 2020

Hepatic effects of repeated halothane anesthetics in the hypoxic rat model.

1 reference

12 December 2020

1 reference

12 December 2020

A model for fatal halothane hepatitis in the guinea pig.

1 reference

12 December 2020

Mitochondrial enzymes in human serum: comparative determinations of glutamate dehydrogenase and mitochondrial aspartate aminotransferase in healthy persons and patients with chronic liver diseases

1 reference

12 December 2020

Circulating microRNAs as potential markers of human drug-induced liver injury

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF03261997

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23137150%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference