(Q39527452)

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Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL).

scientific article published on 31 August 2011

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scholarly article

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11 February 2020

Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL) (English)

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11 February 2020

G protein-coupled receptor

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Christofer S. Tautermann

3

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11 February 2020

4

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11 February 2020

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11 February 2020

Martin J. Lohse

6

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11 February 2020

author name string

Elisa Alvarez-Curto

1

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11 February 2020

Rudi Prihandoko

2

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11 February 2020

Carsten Hoffmann

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11 February 2020

Andrew B Tobin

8

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11 February 2020

Graeme Milligan

9

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11 February 2020

publication date

31 August 2011

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11 February 2020

Molecular Pharmacology

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11 February 2020

80

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11 February 2020

6

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11 February 2020

1033-1046

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11 February 2020

The use of G-protein coupled receptor models in lead optimization

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Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code.

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Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.

1 reference

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Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs

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Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

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Engineered GPCRs as tools to modulate signal transduction

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Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids

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Engineering GPCR signaling pathways with RASSLs

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Location, location, location...site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling

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An engineered protein tag for multiprotein labeling in living cells

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G-protein-coupled receptor phosphorylation: where, when and by whom

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Ligand-stabilized conformational states of human beta(2) adrenergic receptor: insight into G-protein-coupled receptor activation

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Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

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Beta-arrestin-biased ligands at seven-transmembrane receptors

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GPCR functional selectivity has therapeutic impact

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Conformational complexity of G-protein-coupled receptors

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Identifiers

10.1124/MOL.111.074674

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11 February 2020

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11 February 2020

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11 February 2020

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