(Q39584277)

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Targeting PKC-mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid leukemia-derived cell lines and blast cells

scientific article published on June 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Targeting PKC-mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid leukemia-derived cell lines and blast cells (English)

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

1 reference

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inferred from title

Marina Konopleva

8

object named as

Marina Konopleva

1 reference

Europe PubMed Central

13 September 2017

PMC publication ID

Michael Andreeff

9

object named as

Michael Andreeff

1 reference

Europe PubMed Central

13 September 2017

PMC publication ID

1

object named as

Peter P Ruvolo

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Steven M Kornblau

7

object named as

Steven Kornblau

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

4

object named as

Vivian R Ruvolo

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

3

object named as

Julie C Watt

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

6

object named as

Tilahun Jiffar

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

5

object named as

Jared K Burks

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

2

object named as

Liran Zhou

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

publication date

1 June 2011

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Journal of Cellular Biochemistry

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

112

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

6

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

1696-1707

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Protein kinase C: poised to signal

1 reference

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14 September 2017

Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy.

1 reference

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14 September 2017

A phase I trial of enzastaurin in patients with recurrent gliomas

1 reference

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PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells

1 reference

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Spatiotemporal dynamics of lipid signaling: protein kinase C as a paradigm

1 reference

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14 September 2017

Protein kinase C signalling in leukemia

1 reference

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Diagnosing and exploiting cancer's addiction to blocks in apoptosis

1 reference

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14 September 2017

1 reference

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A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma

1 reference

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The protein kinase C (PKC) family of proteins in cytokine signaling in hematopoiesis

1 reference

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14 September 2017

Enzastaurin, a protein kinase Cbeta- selective inhibitor, and its potential application as an anticancer agent in lung cancer

1 reference

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14 September 2017

Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma

1 reference

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14 September 2017

Protein kinase C and other diacylglycerol effectors in cancer

1 reference

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

1 reference

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14 September 2017

Protein kinase C regulatory domains: the art of decoding many different signals in membranes

1 reference

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14 September 2017

Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial

1 reference

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14 September 2017

Direct binding to ceramide activates protein kinase Czeta before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells

1 reference

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14 September 2017

Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits

1 reference

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14 September 2017

Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C.

1 reference

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Regulation of Bcl2 phosphorylation and potential significance for leukemic cell chemoresistance

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BCR-ABL prevents c-jun-mediated and proteasome-dependent FUS (TLS) proteolysis through a protein kinase CbetaII-dependent pathway

1 reference

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Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases

1 reference

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Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

1 reference

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Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis

1 reference

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14 September 2017

Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A

1 reference

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14 September 2017

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid

1 reference

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14 September 2017

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1 reference

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Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641.

1 reference

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Gö6976 is a potent inhibitor of the JAK 2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells

1 reference

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Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway

1 reference

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14 September 2017

Bcr-Abl-mediated molecular mechanism for apoptotic suppression in multipotent haemopoietic cells: a role for PKCbetaII.

1 reference

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14 September 2017

Protein kinase C-alpha overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal

1 reference

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25 September 2017

A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis

1 reference

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25 September 2017

Molecular thanatopsis: a discourse on the BCL2 family and cell death.

1 reference

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25 September 2017

Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia

1 reference

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Critical role for protein phosphatase 2A heterotrimers in mammalian cell survival.

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Phase Ib safety and pharmacokinetic evaluation of daily and twice daily oral enzastaurin in combination with pemetrexed in advanced/metastatic cancer.

1 reference

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1 reference

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21 August 2018

Targeting the protein kinase C family: are we there yet?

1 reference

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Bcl2 phosphorylation and active PKC alpha are associated with poor survival in AML.

1 reference

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The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts

1 reference

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PKC alpha mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation

1 reference

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Antiangiogenic effects of a protein kinase Cbeta-selective small molecule

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Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia

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Activation of protein kinase Calpha inhibits growth of pancreatic cancer cells via p21(cip)-mediated G(1) arrest.

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Altered cytosol/membrane enzyme redistribution on interleukin-3 activation of protein kinase C

1 reference

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Protein kinase C-alpha antagonizes apoptosis induction by histone deacetylase inhibitors in multidrug resistant leukaemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21360576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/21360576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiangiogenic and antitumor effects of a protein kinase Cbeta inhibitor in human breast cancer and ovarian cancer xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21360576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21360576

12 December 2020

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inferred from PubMed ID database lookup

Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A

1 reference

https://pubmed.ncbi.nlm.nih.gov/21360576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C beta 1 and protein kinase C beta 2 activate p57 mitogen-activated protein kinase and block differentiation in colon carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21360576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/JCB.23090

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

ResearchGate publication ID

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