(Q39586039)

English

Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals

scientific article published on 24 February 2011

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scholarly article

1 reference

Europe PubMed Central

13 September 2017

Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals (English)

1 reference

Europe PubMed Central

13 September 2017

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1 reference

based on heuristic

inferred from title

chronic lymphocytic leukemia

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based on heuristic

inferred from title

dasatinib monohydrate

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Alison M Michie

4

1 reference

Europe PubMed Central

13 September 2017

object named as

Emilio Cosimo

2

0 references

Alison M McCaig

1

object named as

Alison M McCaig

1 reference

Europe PubMed Central

13 September 2017

author name string

Michael T Leach

3

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Europe PubMed Central

13 September 2017

language of work or name

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publication date

24 February 2011

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Europe PubMed Central

13 September 2017

British Journal of Haematology

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Europe PubMed Central

13 September 2017

153

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Europe PubMed Central

13 September 2017

2

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Europe PubMed Central

13 September 2017

199-211

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Europe PubMed Central

13 September 2017

Primary del 17 chronic lymphocytic leukaemia lymphocytes are hypersensitive to dasatinib in vitro

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Heat shock protein 90 as a drug target: some like it hot.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

The microenvironment in mature B-cell malignancies: a target for new treatment strategies

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

B cell antigen receptor signaling 101.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Survival response to B-cell receptor ligation is restricted to progressive chronic lymphocytic leukemia cells irrespective of Zap70 expression.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Differential heat shock protein localization in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Microenvironmental influences in chronic lymphocytic leukaemia: the role of antigen stimulation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

The novel nuclear factor-kappaB inhibitor LC-1 is equipotent in poor prognostic subsets of chronic lymphocytic leukemia and shows strong synergy with fludarabine

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Therapeutic implications of Src independent calcium mobilization in diffuse large B-cell lymphoma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Rituximab and 17-allylamino-17-demethoxygeldanamycin induce synergistic apoptosis in B-cell chronic lymphocytic leukaemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

ITAM-mediated tonic signalling through pre-BCR and BCR complexes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Activities of SYK and PLCgamma2 predict apoptotic response of CLL cells to SRC tyrosine kinase inhibitor dasatinib.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Chronic lymphocytic leukemia: revelations from the B-cell receptor.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

CD154 induces a switch in pro-survival Bcl-2 family members in chronic lymphocytic leukaemia.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Separate cell culture conditions to promote proliferation or quiescent cell survival in chronic lymphocytic leukemia.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Tyrosine kinase inhibition in diffuse large B-cell lymphoma: molecular basis for antitumor activity and drug resistance of dasatinib.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

c-Abl Expression in Chronic Lymphocytic Leukemia Cells: Clinical and Therapeutic Implications

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Dasatinib sensitizes primary chronic lymphocytic leukaemia lymphocytes to chlorambucil and fludarabinein vitro

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2010.08507.X

21 January 2018

Identifiers

10.1111/J.1365-2141.2010.08507.X

1 reference

Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

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