(Q39657050)

13 September 2017

title

Use of the γH2AX assay for assessing the genotoxicity of polycyclic aromatic hydrocarbons in human cell lines (English)

1 reference

polycyclic aromatic hydrocarbons

13 September 2017

1 reference

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20832459

10 July 2024

J-P Cravedi

7

1 reference

13 September 2017

A. Riu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20832459

10 July 2024

C. Jacques

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20832459

10 July 2024

A. Hillenweck

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20832459

10 July 2024

D. Zalko

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20832459

10 July 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20832459

10 July 2024

publication date

9 September 2010

1 reference

full work available at URL

13 September 2017

https://api.elsevier.com/content/article/PII:S0378427410016735?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/J.TOXLET.2010.08.022

https://api.elsevier.com/content/article/PII:S0378427410016735?httpAccept=text/plain

10 July 2024

1 reference

https://api.crossref.org/works/10.1016/J.TOXLET.2010.08.022

10 July 2024

1 reference

13 September 2017

volume

199

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13 September 2017

issue

2

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13 September 2017

page(s)

182-192

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Absence of HeLa cell contamination in 169 cell lines derived from human tumors

13 September 2017

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GammaH2AX, an accurate marker that analyzes UV genotoxic effects on human keratinocytes and on human skin.

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Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

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Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites

10 July 2024

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Biotransformation of genistein and bisphenol A in cell lines used for screening endocrine disruptors

10 July 2024

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The approach to understanding aromatic hydrocarbon carcinogenesis. The central role of radical cations in metabolic activation

10 July 2024

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A cell-based immunocytochemical assay for monitoring kinase signaling pathways and drug efficacy

10 July 2024

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Feasibility of a simple double-layered coculture system incorporating metabolic processes of the intestine and liver tissue: application to the analysis of benzo[a]pyrene toxicity

10 July 2024

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The comet assay: topical issues.

10 July 2024

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The influence of culture medium composition on drug metabolising enzyme activities of the human liver derived Hep G2 cell line

10 July 2024

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A lifetime passion for micronucleus cytome assays--reflections from Down Under

10 July 2024

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Novel genotoxicity assays identify norethindrone to activate p53 and phosphorylate H2AX.

10 July 2024

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Contribution of human cytochrome P450 to benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol metabolism, as predicted from heterologous expression in yeast.

10 July 2024

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

10 July 2024

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Benzo-a-pyrene: environmental partitioning and human exposure

10 July 2024

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Characterization of biliary metabolites of fluoranthene in the common sole (Solea solea).

10 July 2024

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Augmentation of 3-methylcholanthrene-induced bioactivation in the human hepatoma cell line HepG2 by the calcium channel blocker nicardipine

10 July 2024

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The gamma-H2A.X: is it just a surrogate marker of double-strand breaks or much more?

10 July 2024

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An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans

10 July 2024

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Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences

10 July 2024

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Characterisation of B(a)P metabolites formed in an ex vivo pig skin model using three complementary analytical methods

10 July 2024

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DNA double-strand breaks: signaling, repair and the cancer connection

10 July 2024

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Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1

10 July 2024

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How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop

10 July 2024

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Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo(a)pyrene and their mode of action

10 July 2024

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Assessment of in vivo genotoxicity of the rodent carcinogen furan: evaluation of DNA damage and induction of micronuclei in mouse splenocytes

10 July 2024

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Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines

10 July 2024

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Influence of the metabolic properties of human cells on the kinetic of formation of the major benzo[a]pyrene DNA adducts

10 July 2024

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The role of DNA breaks in genomic instability and tumorigenesis

10 July 2024

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Induction of cytochrome P450-dependent monooxygenase in serum-free cultured Hep G2 cells

10 July 2024

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Generation of Reactive Oxygen Species during the Enzymatic Oxidation of Polycyclic Aromatic Hydrocarbontrans-Dihydrodiols Catalyzed by Dihydrodiol Dehydrogenase

10 July 2024

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Detection of xenobiotic-induced DNA damage by the comet assay applied to human and rat precision-cut liver slices

10 July 2024

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10 July 2024

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

10 July 2024

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Different mechanisms of handling ingested polycyclic aromatic hydrocarbons in mammalian species: organ-specific response patterns of CYP1A1-induction after oral intake of PAH-contaminated soils

10 July 2024

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Accumulation of DSBs in gamma-H2AX domains fuel chromosomal aberrations

10 July 2024

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Regulation of CYP1A1 gene expression by the antioxidant tert-butylhydroquinone

10 July 2024

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Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbons

10 July 2024

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Relevance of different biological assays in assessing initiating and promoting properties of polycyclic aromatic hydrocarbons with respect to carcinogenic potency.

10 July 2024

52

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Assessment of the potential in vivo genotoxicity of fluoranthene

10 July 2024

53

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https://api.crossref.org/works/10.1016/J.TOXLET.2010.08.022

Benzo (alpha) pyrene metabolism by isolated rat intestinal epithelial cells

10 July 2024

54

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3-Methylcholanthrene displays dual effects on estrogen receptor (ER) alpha and ER beta signaling in a cell-type specific fashion.

10 July 2024

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Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants

10 July 2024

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Extent of constitutive histone H2AX phosphorylation on Ser-139 varies in cells with different TP53 status

10 July 2024

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Relative contribution of DNA strand breaks and DNA adducts to the genotoxicity of benzo[a]pyrene as a pure compound and in complex mixtures

10 July 2024

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Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice

10 July 2024

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Expression of aryl hydrocarbon receptor repressor in normal human tissues and inducibility by polycyclic aromatic hydrocarbons in human tumor-derived cell lines

10 July 2024

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CYP1A1 and CYP1A2 expression: comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines

10 July 2024

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On the bioactivation and genotoxic action of fluoranthene

10 July 2024

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Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays.

10 July 2024

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Regulation and mechanisms of mammalian double-strand break repair

10 July 2024

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The liver plays a central role in the mechanism of chemical carcinogenesis due to polycyclic aromatic hydrocarbons

10 July 2024

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DNA ligase III as a candidate component of backup pathways of nonhomologous end joining

10 July 2024

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Induction of lung and liver tumors by fluoranthene in a preweanling CD-1 mouse bioassay

10 July 2024

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Formation and persistence of DNA adducts in organs of CD-1 mice treated with a tumorigenic dose of fluoranthene

10 July 2024

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Mutations of the Ki-ras protooncogene in 3-methylcholanthrene and urethan-induced and butylated hydroxytoluene-promoted lung tumors of strain A/J and SWR mice

10 July 2024

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H2AX phosphorylation as a genotoxicity endpoint.

10 July 2024

70

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Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells

10 July 2024

71

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Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition

10 July 2024

72

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Use of four new human-derived liver-cell lines for the detection of genotoxic compounds in the single-cell gel electrophoresis (SCGE) assay.

10 July 2024

73

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Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review

10 July 2024

74

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Phosphorylated H2AX foci in tumor cells have no correlation with their radiation sensitivities

10 July 2024

75

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Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability.

10 July 2024

76

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A comparative study of using comet assay and gammaH2AX foci formation in the detection of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA damage

10 July 2024

77

1 reference

https://api.crossref.org/works/10.1016/J.TOXLET.2010.08.022

DNA damage evaluated by gammaH2AX foci formation by a selective group of chemical/physical stressors

10 July 2024

78

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https://api.crossref.org/works/10.1016/J.TOXLET.2010.08.022

10 July 2024

Identifiers

1 reference

13 September 2017

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