(Q39671003)

English

Protoapigenone, a natural derivative of apigenin, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with induction of oxidative stress and inhibition of glutathione S-transferase π

scientific article published on August 5, 2010

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scholarly article

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Europe PubMed Central

PubMed publication ID

13 September 2017

Protoapigenone, a natural derivative of apigenin, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with induction of oxidative stress and inhibition of glutathione S-transferase π (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20686818

17 June 2024

1 reference

based on heuristic

inferred from title

Fang-Rong Chang

5

object named as

Fang-Rong Chang

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20686818

17 June 2024

author name string

Wen-Ying Chen

1

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Yu-An Hsieh

2

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Ching-I Tsai

3

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Ya-Fei Kang

4

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Yang-Chang Wu

6

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Chin-Chung Wu

7

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

language of work or name

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20686818

17 June 2024

publication date

5 August 2010

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Investigational New Drugs

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

29

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

1347-1359

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

https://scigraph.springernature.com/pub.10.1007/s10637-010-9497-0

0 references

Cancer statistics, 2006

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Cell death and cancer therapy

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Flavonoids: old and new aspects of a class of natural therapeutic drugs

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

The biochemistry and medical significance of the flavonoids

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

New cytotoxic flavonoids from Thelypteris torresiana

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Protoapigenone, a novel flavonoid, inhibits ovarian cancer cell growth in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Protoapigenone, a novel flavonoid, induces apoptosis in human prostate cancer cells through activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase 1/2.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Goniothalamin induces cell cycle-specific apoptosis by modulating the redox status in MDA-MB-231 cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Protein disulfide bond formation in the cytoplasm during oxidative stress

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

The natural diterpenoid ovatodiolide induces cell cycle arrest and apoptosis in human oral squamous cell carcinoma Ca9-22 cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

The p38 signal transduction pathway: activation and function

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Signal transduction by the JNK group of MAP kinases

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

JNK is associated with Bcl-2 and PP1 in mitochondria: paclitaxel induces its activation and its association with the phosphorylated form of Bcl-2.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Mitochondrial reactive oxygen species in cell death signaling

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Mitogen-activated protein kinases modulate H(2)O(2)-induced apoptosis in primary rat alveolar epithelial cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Regulation of JNK signaling by GSTp

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Stress-responsive protein kinases in redox-regulated apoptosis signaling

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Mitogen-activated protein kinases in apoptosis regulation

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Cellular response to oxidative stress: signaling for suicide and survival

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Taxol-induced mitochondrial stress in melanoma cells is mediated by activation of c-Jun N-terminal kinase (JNK) and p38 pathways via uncoupling protein 2.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Reactive oxygen species mediate crosstalk between NF-kappaB and JNK.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Novel role for JNK as a stress-activated Bcl2 kinase

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Interleukin-3 induces the phosphorylation of a distinct fraction of bcl-2.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Role of reactive oxygen species (ROS) in apoptosis induction

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Apigenin Induces Apoptosis through Proteasomal Degradation of HER2/neu in HER2/neu-overexpressing Breast Cancer Cells via the Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Accumulation of hypoxia-inducible factor-1alpha through a novel electrophilic, thiol antioxidant-sensitive mechanism

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Kinetic glutathione chemoassay to quantify thiol reactivity of organic electrophiles--application to alpha,beta-unsaturated ketones, acrylates, and propiolates

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Elucidation of thioredoxin as a molecular target for antitumor quinols.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Tubocapsenolide A, a novel withanolide, inhibits proliferation and induces apoptosis in MDA-MB-231 cells by thiol oxidation of heat shock proteins.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Stereoselective conjugation of prostaglandin A2 and prostaglandin J2 with glutathione, catalyzed by the human glutathione S-transferases A1-1, A2-2, M1a-1a, and P1-1.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Inhibition of human glutathione S-transferase P1-1 by the flavonoid quercetin

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

GST function in drug and stress response

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

The role of glutathione-S-transferase in anti-cancer drug resistance

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Bcl-2 Phosphorylation by p38 MAPK

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9497-0

21 January 2018

Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ERK cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/20686818

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20686818

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of cysteine residues involved in disulfide formation in the inactivation of glutathione transferase P-form by hydrogen peroxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/20686818

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apigenin and cancer chemoprevention: progress, potential and promise (review).

1 reference

https://pubmed.ncbi.nlm.nih.gov/20686818

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione S-transferases. The first enzymatic step in mercapturic acid formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20686818

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethacrynic acid butyl-ester induces apoptosis in leukemia cells through a hydrogen peroxide mediated pathway independent of glutathione S-transferase P1-1 inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/20686818

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thiol depletion induces apoptosis in cultured lung fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/20686818

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/20686818

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of Bcl2 and regulation of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20686818

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of p38 MAPK and JNK in enhanced cervical cancer cell killing by the combination of arsenic trioxide and ionizing radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20686818

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20686818

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10637-010-9497-0

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

release_vt5suw5ymzcj3cqrvigvf7nu5e

1 reference

https://api.fatcat.wiki/v0/release/vt5suw5ymzcj3cqrvigvf7nu5e

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

ResearchGate publication ID

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