(Q39700222)

14 September 2017

A novel BH3 mimetic S1 potently induces Bax/Bak-dependent apoptosis by targeting both Bcl-2 and Mcl-1. (English)

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14 September 2017

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Zhichao Zhang

1

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14 September 2017

Ting Song

2

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14 September 2017

Tiantai Zhang

3

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14 September 2017

Jin Gao

4

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14 September 2017

Guiye Wu

5

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14 September 2017

Lijia An

6

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14 September 2017

Guanhua Du

7

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14 September 2017

language of work or name

English

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publication date

25 May 2010

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International Journal of Cancer

14 September 2017

12

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based on heuristic

inferred from page(s)

published in

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14 September 2017

128

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14 September 2017

7

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14 September 2017

1724-1735

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Control of mitochondrial apoptosis by the Bcl-2 family

14 September 2017

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

21 January 2018

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Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

21 January 2018

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Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy.

21 January 2018

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Cutting-edge apoptosis-based therapeutics: a panacea for cancer?

21 January 2018

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

21 January 2018

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

21 January 2018

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Unique biology of Mcl-1: therapeutic opportunities in cancer

21 January 2018

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Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70.

21 January 2018

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Novel Bcl-2 inhibitors: Discovery and mechanism study of small organic apoptosis-inducing agents

21 January 2018

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BIM and tBID are not mechanistically equivalent when assisting BAX to permeabilize bilayer membranes

21 January 2018

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(-)-Epigallocatechin-3-gallate induces apoptosis of human hepatoma cells by mitochondrial pathways related to reactive oxygen species.

21 January 2018

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MAP-1 is a mitochondrial effector of Bax.

21 January 2018

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Elucidation of some Bax conformational changes through crystallization of an antibody-peptide complex

21 January 2018

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A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells

21 January 2018

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

21 January 2018

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

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Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins.

21 January 2018

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Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation.

21 January 2018

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BH3 mimetics to improve cancer therapy; mechanisms and examples

21 January 2018

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Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

21 January 2018

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Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation.

21 January 2018

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Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

21 January 2018

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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

21 January 2018

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.25484

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14 September 2017

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