(Q39714583)

14 September 2017

title

A p38(MAPK)/HIF-1 pathway initiated by UVB irradiation is required to induce Noxa and apoptosis of human keratinocytes (English)

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14 September 2017

7

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14 September 2017

3

Carine Michiels

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author name string

Kris Nys

1

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14 September 2017

An Van Laethem

2

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14 September 2017

Noemi Rubio

4

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14 September 2017

Jacques G Piette

5

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14 September 2017

Maria Garmyn

6

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14 September 2017

language of work or name

English

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publication date

15 April 2010

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Journal of Investigative Dermatology

14 September 2017

published in

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14 September 2017

volume

130

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14 September 2017

issue

9

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14 September 2017

page(s)

2269-2276

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https://scigraph.springernature.com/pub.10.1038/jid.2010.93

14 September 2017

exact match

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cites work

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p53 and the pathogenesis of skin cancer

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Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.

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Knockdown of p53 levels in human keratinocytes accelerates Mcl-1 and Bcl-x(L) reduction thereby enhancing UV-light induced apoptosis

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Early ultraviolet B-induced G1 arrest and suppression of the malignant phenotype by wild-type p53 in human squamous cell carcinoma cells

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UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer

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Hypoxia regulates inflammatory gene expression in endothelial cells

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Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains

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In vitro assessment of keratinocyte aging

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7 January 2021

Apoptotic pathways: ten minutes to dead

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7 January 2021

Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53

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https://api.crossref.org/works/10.1038%2FJID.2010.93

7 January 2021

Functional linkage between NOXA and Bim in mitochondrial apoptotic events

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Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response

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Coping with stress: multiple ways to activate p53.

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Regulation of the ring finger E3 ligase Siah2 by p38 MAPK.

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7 January 2021

BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha

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BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF.

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7 January 2021

Independent contribution of three different pathways to ultraviolet-B-induced apoptosis

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Signal pathway of hypoxia-inducible factor-1alpha phosphorylation and its interaction with von Hippel-Lindau tumor suppressor protein during ischemia in MiaPaCa-2 pancreatic cancer cells.

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BH3-only proteins in apoptosis and beyond: an overview

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The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response.

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7 January 2021

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

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https://api.crossref.org/works/10.1038%2FJID.2010.93

7 January 2021

Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.

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Is HIF-1alpha a pro- or an anti-apoptotic protein?

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Noxa: at the tip of the balance between life and death.

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Redox regulation of the hypoxia-inducible factor

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p63 expression in normal skin and usual cutaneous carcinomas

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7 January 2021

Hypoxia-inducible factor-1alpha, a key factor in the keratinocyte response to UVB exposure

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https://api.crossref.org/works/10.1038%2FJID.2010.93

7 January 2021

Hypoxia-inducible factor 1 (HIF-1) pathway

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.93

7 January 2021

Activation of p38 mitogen-activated protein kinase and caspases in UVB-induced apoptosis of human keratinocyte HaCaT cells

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https://api.crossref.org/works/10.1038%2FJID.2010.93

7 January 2021

Mcl-1 functions as major epidermal survival protein required for proper keratinocyte differentiation

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7 January 2021

Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes

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7 January 2021

In vitro and in vivo transfer of bcl-2 gene into keratinocytes suppresses UVB-induced apoptosis.

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7 January 2021

Apoptosis signal regulating kinase-1 connects reactive oxygen species to p38 MAPK-induced mitochondrial apoptosis in UVB-irradiated human keratinocytes

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https://api.crossref.org/works/10.1038%2FJID.2010.93

7 January 2021

Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes

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https://api.crossref.org/works/10.1038%2FJID.2010.93

7 January 2021

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

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https://api.crossref.org/works/10.1038%2FJID.2010.93

7 January 2021

The BCL-2 protein family: opposing activities that mediate cell death

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https://api.crossref.org/works/10.1038%2FJID.2010.93

7 January 2021

Sunburn and p53 in the onset of skin cancer

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https://api.crossref.org/works/10.1038%2FJID.2010.93

7 January 2021

Identifiers

DOI

10.1038/JID.2010.93

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14 September 2017

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