(Q39732707)

English

Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

author name string

H K Crewe

1

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Z E Barter

2

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

K Rowland Yeo

3

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

A Rostami-Hodjegan

4

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

publication date

4 July 2011

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Biopharmaceutics and Drug Disposition

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Europe PubMed Central

PubMed publication ID

14 September 2017

32

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

303-318

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

The use of heterologously expressed drug metabolizing enzymes--state of the art and prospects for the future

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Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans

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Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

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A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recogn

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Utility of recombinant cytochrome p450 enzymes: a drug metabolism perspective.

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Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors

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Sources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model

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Inter-individual variability in levels of human microsomal protein and hepatocellularity per gram of liver

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Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance.

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Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data

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The human intestinal cytochrome P450 "pie".

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Covariation of human microsomal protein per gram of liver with age: absence of influence of operator and sample storage may justify interlaboratory data pooling

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Changes in liver volume from birth to adulthood: a meta-analysis.

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Prediction of intestinal first-pass drug metabolism

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Fluvoxamine inhibits the CYP2C9 catalyzed biotransformation of tolbutamide.

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Enzyme source effects on CYP2C9 kinetics and inhibition

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Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochromes P450.

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21 January 2018

Validated assays for human cytochrome P450 activities

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Role of cytochrome P450 2C9 and an allelic variant in the 4'-hydroxylation of (R)- and (S)-flurbiprofen

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Inhibition of CYP2C9 by selective serotonin reuptake inhibitors: in vitro studies with tolbutamide and (S)-warfarin using human liver microsomes.

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21 January 2018

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--towards a consensus

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Crystal structure of human cytochrome P450 2C9 with bound warfarin

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Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions.

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Influence of fluorescent probe size and cytochrome b5 on drug-drug interactions in CYP2C9.

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CYP2C9 protein interactions with cytochrome b(5): effects on the coupling of catalysis

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Predictions of the in vivo clearance of drugs from rate of loss using human liver microsomes for phase I and phase II biotransformations.

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Comparison between recombinant P450s and human liver microsomes in the determination of cytochrome P450 Michaelis-Menten constants.

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Identifiers

10.1002/BDD.760

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

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