(Q48276802)

English

Sources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model

scientific article published on 24 March 2011

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/21434772

Sources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/21434772

pharmacokinetics

1 reference

based on heuristic

inferred from title

author name string

Helen E Cubitt

1

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/21434772

Karen R Yeo

2

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/21434772

Eleanor M Howgate

3

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/21434772

Amin Rostami-Hodjegan

4

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/21434772

Zoe E Barter

5

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/21434772

language of work or name

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publication date

24 March 2011

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/21434772

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/21434772

41

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/21434772

8

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/21434772

623-638

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/21434772

Midazolam kinetics.

1 reference

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21 January 2018

The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin.

1 reference

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21 January 2018

Coadministration of nefazodone and benzodiazepines: II. A pharmacokinetic interaction study with triazolam

1 reference

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21 January 2018

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

1 reference

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21 January 2018

Covariation of human microsomal protein per gram of liver with age: absence of influence of operator and sample storage may justify interlaboratory data pooling

1 reference

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21 January 2018

Determination of a quantitative relationship between hepatic CYP3A5*1/*3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populations

1 reference

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21 January 2018

Characterization of the rhesus monkey CYP3A64 enzyme: species comparisons of CYP3A substrate specificity and kinetics using baculovirus-expressed recombinant enzymes

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21 January 2018

Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochromes P450.

1 reference

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21 January 2018

Effect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro

1 reference

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21 January 2018

Interaction profile of armodafinil with medications metabolized by cytochrome P450 enzymes 1A2, 3A4 and 2C19 in healthy subjects

1 reference

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21 January 2018

Pharmacokinetics and Pharmacodynamics of Triazolam After Two Intermittent Doses in Obese and Normal-Weight Men

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21 January 2018

Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment

1 reference

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21 January 2018

Triazolam disposition

1 reference

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21 January 2018

Comparative pharmacokinetics and pharmacodynamics of lorazepam, alprazolam and diazepam

1 reference

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21 January 2018

Enzymatic characteristics of CYP3A5 and CYP3A4: a comparison of in vitro kinetic and drug-drug interaction patterns.

1 reference

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21 January 2018

Relative roles of CYP2C19 and CYP3A4/5 in midazolam 1'-hydroxylation

1 reference

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21 January 2018

In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole.

1 reference

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21 January 2018

Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice

1 reference

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21 January 2018

Lack of correlation between in vitro inhibition of CYP3A-mediated metabolism by a PPAR-gamma agonist and its effect on the clinical pharmacokinetics of midazolam, an in vivo probe of CYP3A activity

1 reference

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21 January 2018

A pharmacokinetic and pharmacodynamic evaluation of the combined administration of alprazolam and fluvoxamine.

1 reference

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21 January 2018

Utility of recombinant enzyme kinetics in prediction of human clearance: impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates.

1 reference

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21 January 2018

Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data.

1 reference

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21 January 2018

The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo

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21 January 2018

The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity

1 reference

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21 January 2018

Reduced clearance of triazolam in old age: relation to antipyrine oxidizing capacity

1 reference

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21 January 2018

Kinetics and EEG effects of midazolam during and after 1-minute, 1-hour, and 3-hour intravenous infusions.

1 reference

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21 January 2018

Comparative single-dose kinetics and dynamics of lorazepam, alprazolam, prazepam, and placebo

1 reference

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21 January 2018

Pharmacokinetics and bioavailability of midazolam in man

1 reference

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21 January 2018

Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus

1 reference

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21 January 2018

In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans

1 reference

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21 January 2018

Incorporation of in vitro drug metabolism data into physiologically-based pharmacokinetic models

1 reference

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21 January 2018

Methods for predicting in vivo pharmacokinetics using data from in vitro assays

1 reference

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21 January 2018

Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability

1 reference

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21 January 2018

Evidence of significant contribution from CYP3A5 to hepatic drug metabolism

1 reference

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21 January 2018

In vitro and in vivo glucuronidation of midazolam in humans

1 reference

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21 January 2018

Estimation of the interindividual variability of cytochrome 2D6 activity from urinary metabolic ratios in the literature

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21 January 2018

The Simcyp population-based ADME simulator

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21 January 2018

Changes in liver volume from birth to adulthood: a meta-analysis.

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21 January 2018

Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis

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21 January 2018

Effect of polymorphic CYP3A5 genotype on the single-dose simvastatin pharmacokinetics in healthy subjects.

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21 January 2018

Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A.

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21 January 2018

Impact of Ignoring Extraction Ratio When Predicting Drug-Drug Interactions, Fraction Metabolized, and Intestinal First-Pass Contribution

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21 January 2018

Physiologic and temporal variation in hepatic elimination of midazolam.

1 reference

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21 January 2018

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

1 reference

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21 January 2018

Interaction between grapefruit juice and midazolam in humans*

1 reference

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21 January 2018

Pharmacokinetic and Pharmacodynamic Interactions of Oral Midazolam with Ketoconazole, Fluoxetine, Fluvoxamine, and Nefazodone

1 reference

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21 January 2018

Genetic predictors of interindividual variability in hepatic CYP3A4 expression

1 reference

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21 January 2018

Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: a comparison with nonalcoholics

1 reference

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21 January 2018

Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers.

1 reference

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21 January 2018

In vivo comparisons of constitutive cytochrome P450 3A activity assessed by alprazolam, triazolam, and midazolam

1 reference

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21 January 2018

Evaluation of approach to predict the contribution of multiple cytochrome P450s in drug metabolism using relative activity factor: effects of the differences in expression levels of NADPH-cytochrome P450 reductase and cytochrome b(5) in the expressi

1 reference

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21 January 2018

A potentially hazardous interaction between erythromycin and midazolam.

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21 January 2018

Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors

1 reference

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21 January 2018

The unique complexity of the CYP3A4 upstream region suggests a nongenetic explanation of its expression variability

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21 January 2018

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

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21 January 2018

Pharmacokinetics and pharmacodynamics of alprazolam after oral and IV administration

1 reference

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21 January 2018

Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5.

1 reference

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21 January 2018

Evaluation of recombinant cytochrome P450 enzymes as an in vitro system for metabolic clearance predictions

1 reference

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21 January 2018

CYP3A activity in European American and Japanese men using midazolam as an in vivo probe

1 reference

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21 January 2018

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

1 reference

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21 January 2018

Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: effect of ketoconazole.

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21 January 2018

Kinetics and dynamics of intravenous adinazolam, N-desmethyl adinazolam, and alprazolam in healthy volunteers

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A novel screening strategy to identify ABCB1 substrates and inhibitors

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21 January 2018

Validated assays for human cytochrome P450 activities

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21 January 2018

CYP3A activity in African American and European American men: population differences and functional effect of the CYP3A4*1B5'-promoter region polymorphism

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21 January 2018

Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation

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21 January 2018

Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism

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21 January 2018

Predicting in vivo drug interactions from in vitro drug discovery data

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21 January 2018

Commentary: a physiological approach to hepatic drug clearance

1 reference

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21 January 2018

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

1 reference

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21 January 2018

Inter-individual variability in levels of human microsomal protein and hepatocellularity per gram of liver

1 reference

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21 January 2018

Prediction of intestinal first-pass drug metabolism

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21 January 2018

Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite.

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21 January 2018

Identifiers

10.3109/00498254.2011.560294

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/21434772

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/21434772

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