(Q39746584)

14 September 2017

Plumbagin, isolated from Plumbago zeylanica, induces cell death through apoptosis in human pancreatic cancer cells (English)

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14 September 2017

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Chien-An Chen

1

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14 September 2017

Hen-Hong Chang

2

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14 September 2017

Chung-Yu Kao

3

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14 September 2017

Tung-Hu Tsai

4

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14 September 2017

Yu-Jen Chen

5

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14 September 2017

1 January 2009

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14 September 2017

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14 September 2017

9

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14 September 2017

6

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14 September 2017

797-809

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Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemot

14 September 2017

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Apoptosis: a link between cancer genetics and chemotherapy

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Pancreatic cancer cell proliferation is phosphatidylinositol 3-kinase dependent

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12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Molecular characterization of mitochondrial apoptosis-inducing factor

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

p53 alteration is not an independent prognostic indicator, but affects the efficacy of adjuvant chemotherapy in human pancreatic cancer.

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12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

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12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Mitochondrial control of cell death

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12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts

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12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Pancreatic cancer biology and genetics

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12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Global cancer statistics, 2002

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12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Downstream signalling events regulated by phosphatidylinositol 3-kinase activity.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Pathways of apoptotic and non-apoptotic death in tumour cells

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12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Cancer statistics, 2006

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Apoptosis in cancer: cause and cure

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Focus on pancreas cancer

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12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Targeting apoptosis pathways in cancer therapy

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Immunohistochemical evaluation of K-ras, p53, and HER-2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas: evidence for multistep carcinogenesis

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial

1 reference

12 April 2024

https://opencitations.net/index/api/v1/references/10.1159/000210028

Identifiers

DOI

10.1159/000210028

1 reference

14 September 2017

1 reference