(Q39747442)

14 September 2017

In vitro studies of 3-hydroxy-4-pyridinones and their glycosylated derivatives as potential agents for Alzheimer's disease (English)

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14 September 2017

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Tim Storr

4

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Chris Orvig

object named as

Chris Orvig

10

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author name string

David E Green

1

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14 September 2017

Meryn L Bowen

2

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14 September 2017

Lauren E Scott

3

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14 September 2017

Michael Merkel

5

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14 September 2017

Karin Böhmerle

6

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14 September 2017

Katherine H Thompson

7

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14 September 2017

Brian O Patrick

8

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14 September 2017

Harvey J Schugar

9

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14 September 2017

language of work or name

English

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publication date

11 December 2009

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14 September 2017

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14 September 2017

39

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14 September 2017

6

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14 September 2017

1604-1615

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Alzheimer's disease: the amyloid cascade hypothesis

14 September 2017

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Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

21 January 2018

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Copper, iron and zinc in Alzheimer's disease senile plaques.

21 January 2018

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Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

21 January 2018

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The metallobiology of Alzheimer's disease

21 January 2018

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Therapeutics for Alzheimer's disease based on the metal hypothesis

21 January 2018

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Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

21 January 2018

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Pleomorphic copper coordination by Alzheimer's disease amyloid-beta peptide

21 January 2018

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Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

21 January 2018

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Intramuscular desferrioxamine in patients with Alzheimer's disease

21 January 2018

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Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.

21 January 2018

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Treatment of Alzheimer's disease with clioquinol

21 January 2018

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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

21 January 2018

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Combating Alzheimer's disease with multifunctional molecules designed for metal passivation.

21 January 2018

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Synthesis, characterization, and metal coordinating ability of multifunctional carbohydrate-containing compounds for Alzheimer's therapy.

21 January 2018

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Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer's disease.

21 January 2018

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Glycosylated tetrahydrosalens as multifunctional molecules for Alzheimer's therapy

21 January 2018

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

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Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

21 January 2018

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Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

21 January 2018

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d-penicillamine reduces serum oxidative stress in Alzheimer's disease patients.

21 January 2018

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Benefits and risks of deferiprone in iron overload in Thalassaemia and other conditions: comparison of epidemiological and therapeutic aspects with deferoxamine

21 January 2018

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Active oxygen species formation in synaptosomes exposed to an aluminum chelator

21 January 2018

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Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability

21 January 2018

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Pyropheophorbide 2-deoxyglucosamide: a new photosensitizer targeting glucose transporters

21 January 2018

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Synthesis and anti-HIV activity of glucose-containing prodrugs derived from saquinavir, indinavir and nelfinavir

21 January 2018

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Carbohydrate-bearing 3-hydroxy-4-pyridinonato complexes of gallium(III) and indium(III).

21 January 2018

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In vivo inhibition of beta-glucosidase and beta-mannosidase activity in rats by 2-deoxy-2-fluoro-beta-glycosyl fluorides and recovery of activity in vivo and in vitro

21 January 2018

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Ruthenium(II) Sulfoxide−Maltolato and −Nitroimidazole Complexes: Synthesis and MTT Assay

21 January 2018

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Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases

21 January 2018

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Cloning and characterization of human liver cytosolic beta-glycosidase

21 January 2018

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Antioxidant activity applying an improved ABTS radical cation decolorization assay

21 January 2018

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Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

21 January 2018

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Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis

21 January 2018

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Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease

21 January 2018

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Immersion autometallographic tracing of zinc ions in Alzheimer beta-amyloid plaques

21 January 2018

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Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

21 January 2018

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

21 January 2018

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Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding

21 January 2018

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SIR97: a new tool for crystal structure determination and refinement

21 January 2018

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Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/B918439B

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14 September 2017

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