(Q39756768)

English

Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death (English)

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

1 reference

based on heuristic

inferred from title

Giampaolo Tortora

7

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

author name string

A Teresa Alberobello

1

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Vittoria D'Esposito

2

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Daniela Marasco

3

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Nunzianna Doti

4

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Menotti Ruvo

5

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Roberto Bianco

6

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Iolanda Esposito

8

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Francesca Fiory

9

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Claudia Miele

10

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Francesco Beguinot

11

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Pietro Formisano

12

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

language of work or name

0 references

publication date

31 December 2009

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

285

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

9

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

6563-6572

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1

1 reference

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The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors

1 reference

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New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen

1 reference

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Insulin and insulin-like growth factor signalling in neoplasia

1 reference

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The type 1 insulin-like growth factor receptor pathway

1 reference

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Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors

1 reference

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The life of a cell: apoptosis regulation by the PI3K/PKB pathway

1 reference

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Mechanisms of resistance to ErbB-targeted cancer therapeutics

1 reference

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22 September 2017

Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins

1 reference

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An immunohistochemical perspective of PPAR beta and one of its putative targets PDK1 in normal ovaries, benign and malignant ovarian tumours

1 reference

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The emerging role of the insulin-like growth factor pathway as a therapeutic target in cancer

1 reference

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Insulin-like growth factor receptor as a therapeutic target in head and neck cancer

1 reference

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Overcoming resistance to molecularly targeted anticancer therapies: Rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies

1 reference

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Phase I and pharmacokinetic study of UCN-01 in combination with irinotecan in patients with solid tumors

1 reference

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Growth factor receptor interplay and resistance in cancer

1 reference

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22 September 2017

IGF1R signalling and its inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825452

22 September 2017

The role of the IGF system in cancer growth and metastasis: overview and recent insights

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825452

22 September 2017

Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor: implications for anti-insulin-like growth factor therapy in breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825452

22 September 2017

Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825452

22 September 2017

Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825452

22 September 2017

Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825452

22 September 2017

Type I insulin-like growth factor receptor as a therapeutic target in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825452

22 September 2017

Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825452

22 September 2017

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825452

22 September 2017

PDK1, the master regulator of AGC kinase signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825452

22 September 2017

The new kid on the block(ade) of the IGF-1 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825452

22 September 2017

Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825452

22 September 2017

PDK1 and PKB/Akt: ideal targets for development of new strategies to structure-based drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825452

22 September 2017

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825452

22 September 2017

The receptor for the type I insulin-like growth factor and its ligands regulate multiple cellular functions that impact on metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825452

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IGF-I receptor signalling in transformation and differentiation

1 reference

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Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

1 reference

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22 September 2017

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825452

22 September 2017

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

1 reference

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Gene expression profiles in normal and cancer cells

1 reference

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

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Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3)

1 reference

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Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids

1 reference

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Synthetic peptide sequence from the C-terminus of the insulin-like growth factor-I receptor that induces apoptosis and inhibition of tumor growth

1 reference

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In skeletal muscle, glucose storage and oxidation are differentially impaired by the IR1152 mutant receptor.

1 reference

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Serum IGF-I, IGFBP-3, and matrix metalloproteinase-7 levels and acquired chemo-resistance in advanced colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2825452

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Heterogeneity of receptor function in colon carcinoma cells determined by cross-talk between type I insulin-like growth factor receptor and epidermal growth factor receptor

1 reference

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In NIH-3T3 fibroblasts, insulin receptor interaction with specific protein kinase C isoforms controls receptor intracellular routing

1 reference

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Insulin-like growth factor 1 (IGF-1) alters drug sensitivity of HBL100 human breast cancer cells by inhibition of apoptosis induced by diverse anticancer drugs.

1 reference

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Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor

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1 reference

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1 reference

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Mouse 3-phosphoinositide-dependent protein kinase-1 undergoes dimerization and trans-phosphorylation in the activation loop

1 reference

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20 August 2018

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1 reference

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1 reference

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1 reference

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20 August 2018

Expression of the insulin-like growth factor I receptor C terminus as a myristylated protein leads to induction of apoptosis in tumor cells.

1 reference

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20 August 2018

Advances in male contraception

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.097410

21 January 2018

Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.097410

21 January 2018

Transformation of mammary epithelial cells by 3-phosphoinositide- dependent protein kinase-1 activates beta-catenin and c-Myc, and down-regulates caveolin-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/20044479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and distribution of insulin-like growth factor-1 receptor in human carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/20044479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20044479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass

1 reference

https://pubmed.ncbi.nlm.nih.gov/20044479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.097410

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

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