(Q39849393)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19454690%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

title

PI3K links NKG2D signaling to a CrkL pathway involved in natural killer cell adhesion, polarity, and granule secretion (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19454690%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference

1

1 reference

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28 January 2020

6

Daniel D Billadeau

1 reference

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28 January 2020

author name string

Renee A Schoon

2

1 reference

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28 January 2020

Christopher J Dick

3

1 reference

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28 January 2020

Lucas P Nacusi

4

1 reference

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28 January 2020

Paul J Leibson

5

1 reference

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28 January 2020

language of work or name

English

0 references

publication date

1 June 2009

1 reference

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28 January 2020

published in

Journal of Immunology

1 reference

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28 January 2020

volume

182

1 reference

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28 January 2020

issue

11

1 reference

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28 January 2020

page(s)

6933-6942

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19454690%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

28 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2706535/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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T cell activation and the cytoskeleton: you can't have one without the other

22 September 2017

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JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity

22 September 2017

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Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse

22 September 2017

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Small GTPases and LFA-1 reciprocally modulate adhesion and signaling

22 September 2017

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WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse.

22 September 2017

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Many NK cell receptors activate ERK2 and JNK1 to trigger microtubule organizing center and granule polarization and cytotoxicity

22 September 2017

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Rap1: a key regulator in cell-cell junction formation

22 September 2017

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Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

22 September 2017

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Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion

22 September 2017

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NKG2D-mediated activation of cytotoxic lymphocytes: unique signaling pathways and distinct functional outcomes

22 September 2017

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NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells

22 September 2017

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Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells.

22 September 2017

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The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

22 September 2017

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The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors

22 September 2017

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Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac

22 September 2017

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Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.

22 September 2017

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The mature activating natural killer cell immunologic synapse is formed in distinct stages

22 September 2017

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22 September 2017

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NKG2D-DAP10 triggers human NK cell–mediated killing via a Syk-independent regulatory pathway

22 September 2017

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The role of Rap1 in integrin-mediated cell adhesion

22 September 2017

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Visualization of signaling pathways and cortical cytoskeleton in cytolytic and noncytolytic natural killer cell immune synapses.

22 September 2017

1 reference

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Cell adhesion and polarity during immune interactions

22 September 2017

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22 September 2017

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T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of phosphatidylinositol 3-kinase (p85) via a complex mechanism involving the Cbl protein

22 September 2017

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Differential interaction of Cbl with Grb2 and CrkL in CD2-mediated NK cell activation

22 September 2017

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22 September 2017

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Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells

22 September 2017

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An activating immunoreceptor complex formed by NKG2D and DAP10

22 September 2017

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Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA

22 September 2017

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SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors

22 September 2017

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The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing

22 September 2017

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Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells

22 September 2017

1 reference

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Leukocyte adhesion deficiency type 1 (LAD-1)/variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins

22 September 2017

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Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706535

Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706535

Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706535

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706535

Role for adapter proteins in costimulatory signals of CD2 and IL-2 on NK cell activation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706535

Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706535

Rapid Ca2+-mediated activation of Rap1 in human platelets

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706535

CD11a-c/CD18 and GP84 (LB-2) adhesion molecules on human large granular lymphocytes and their participation in natural killing.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706535

Signal transduction during human natural killer cell activation: inositol phosphate generation and regulation by cyclic AMP.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706535

Centrosome polarization delivers secretory granules to the immunological synapse.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706535

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706535

CTL-associated antigen-4 ligation induces rapid T cell polarization that depends on phosphatidylinositol 3-kinase, Vav-1, Cdc42, and myosin light chain kinase

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706535

Vav1 Controls DAP10-Mediated Natural Cytotoxicity by Regulating Actin and Microtubule Dynamics

4 November 2018

1 reference

12 December 2020

Activating Ly-49 receptors regulate LFA-1-mediated adhesion by NK cells

1 reference

12 December 2020

Functional characterization of LFA-1 antigens in the interaction of human NK clones and target cells

1 reference

12 December 2020

The Severe and Moderate Phenotypes of Heritable Mac-1, LFA-1 Deficiency: Their Quantitative Definition and Relation to Leukocyte Dysfunction and Clinical Features

1 reference

12 December 2020

Defective neutrophil and lymphocyte function in leucocyte adhesion deficiency

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.0803840

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19454690%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19454690%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

PubMed publication ID

19454690

1 reference