(Q39866360)

15 September 2017

title

DNA end-processing enzyme polynucleotide kinase as a potential target in the treatment of cancer (English)

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15 September 2017

Sarah L Allinson

1

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15 September 2017

language of work or name

English

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publication date

1 June 2010

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15 September 2017

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15 September 2017

volume

6

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15 September 2017

issue

6

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15 September 2017

page(s)

1031-1042

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The emerging role of DNA repair proteins as predictive, prognostic and therapeutic targets in cancer

15 September 2017

cites work

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DNA repair pathways as targets for cancer therapy

21 January 2018

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Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage

21 January 2018

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Molecular characterization of a human DNA kinase

21 January 2018

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Human polynucleotide kinase participates in repair of DNA double-strand breaks by nonhomologous end joining but not homologous recombination

21 January 2018

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Involvement of polynucleotide kinase in a poly(ADP-ribose) polymerase-1-dependent DNA double-strand breaks rejoining pathway

21 January 2018

1 reference

Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining

21 January 2018

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Repair of DNA strand gaps and nicks containing 3'-phosphate and 5'-hydroxyl termini by purified mammalian enzymes

21 January 2018

1 reference

Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends

21 January 2018

1 reference

AP endonuclease-independent DNA base excision repair in human cells

21 January 2018

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Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage.

21 January 2018

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DNA 3'-phosphatase activity is critical for rapid global rates of single-strand break repair following oxidative stress

21 January 2018

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Mutations in PNKP cause microcephaly, seizures and defects in DNA repair

21 January 2018

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The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase

21 January 2018

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The phosphatase activity of mammalian polynucleotide kinase takes precedence over its kinase activity in repair of single strand breaks

21 January 2018

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Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase.

21 January 2018

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XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair

21 January 2018

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Mammalian single-strand break repair: mechanisms and links with chromatin

21 January 2018

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XRCC1 stimulates polynucleotide kinase by enhancing its damage discrimination and displacement from DNA repair intermediates

21 January 2018

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The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks

21 January 2018

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Independent mechanisms of stimulation of polynucleotide kinase/phosphatase by phosphorylated and non-phosphorylated XRCC1.

21 January 2018

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End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair

21 January 2018

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Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

21 January 2018

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A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

21 January 2018

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Cadmium and copper inhibit both DNA repair activities of polynucleotide kinase.

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Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

21 January 2018

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APE1 is the major 3'-phosphoglycolate activity in human cell extracts

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Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin

21 January 2018

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TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo

21 January 2018

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TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks

21 January 2018

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Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

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DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes

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The role of Gemtuzumab Ozogamicin in the treatment of acute myeloid leukemia patients

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DNA polymerase beta is the major dRP lyase involved in repair of oxidative base lesions in DNA by mammalian cell extracts

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NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells

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Isolation of a small molecule inhibitor of DNA base excision repair.

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Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay

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A novel inhibitor of DNA polymerase beta enhances the ability of temozolomide to impair the growth of colon cancer cells

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Small-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation

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Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

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Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.

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Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents

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A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

21 January 2018

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Interfering with disease: a progress report on siRNA-based therapeutics

21 January 2018

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Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase

21 January 2018

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Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase

21 January 2018

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4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer

21 January 2018

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Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models

21 January 2018

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Replication-dependent radiosensitization of human glioma cells by inhibition of poly(ADP-Ribose) polymerase: mechanisms and therapeutic potential

21 January 2018

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Polynucleotide kinase as a potential target for enhancing cytotoxicity by ionizing radiation and topoisomerase I inhibitors

21 January 2018

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Real-time monitoring of the activity and kinetics of T4 polynucleotide kinase by a singly labeled DNA-hairpin smart probe coupled with lambda exonuclease cleavage

21 January 2018

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Real-time investigation of nucleic acids phosphorylation process using molecular beacons

21 January 2018

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Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

21 January 2018

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Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions

21 January 2018

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Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK

21 January 2018

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A high-throughput fluorescence polarization assay for signal transducer and activator of transcription 3.

21 January 2018

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The Pfam protein families database

21 January 2018

1 reference

Aprataxin, a novel protein that protects against genotoxic stress

21 January 2018

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Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein

21 January 2018

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A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment

21 January 2018

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The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4

21 January 2018

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APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks

21 January 2018

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APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation

21 January 2018

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

21 January 2018

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The expanding field of poly(ADP-ribosyl)ation reactions. 'Protein Modifications: Beyond the Usual Suspects' Review Series.

21 January 2018

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Reactive oxygen and nitrogen species induce protein and DNA modifications driving arthrofibrosis following total knee arthroplasty

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/FON.10.40

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15 September 2017

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