(Q39869987)

15 September 2017

title

Substituted imidazopyridines as potent inhibitors of HCV replication (English)

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15 September 2017

Jan Paeshuyse

2

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Erik De Clercq

object named as

Erik De Clercq

9

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Johan Neyts

object named as

Johan Neyts

16

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Eric Mabery

7

object named as

Eric Mabery

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15 September 2017

8

Nina Boddeker

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15 September 2017

15

Gerhard Pürstinger

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15 September 2017

1

Inge Vliegen

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15 September 2017

3

Tine De Burghgraeve

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15 September 2017

Laura S Lehman

4

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15 September 2017

Matthew Paulson

5

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15 September 2017

I-Hung Shih

6

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15 September 2017

Hans Reiser

10

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15 September 2017

David Oare

11

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15 September 2017

William A Lee

12

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15 September 2017

Weidong Zhong

13

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15 September 2017

Steven Bondy

14

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15 September 2017

publication date

26 February 2009

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15 September 2017

published in

Journal of Hepatology

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15 September 2017

volume

50

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15 September 2017

issue

5

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15 September 2017

page(s)

999-1009

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Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

15 September 2017

cites work

1 reference

12 December 2020

Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase

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12 December 2020

Cyclophilin inhibitors in hepatitis C viral infection

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12 December 2020

Ribavirin Antagonizes the In Vitro Anti-Hepatitis C Virus Activity of 2'-C-Methylcytidine, the Active Component of Valopicitabine

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12 December 2020

Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial

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12 December 2020

Current and future hepatitis C therapies

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12 December 2020

P4 and P1' optimization of bicycloproline P2 bearing tetrapeptidyl alpha-ketoamides as HCV protease inhibitors

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12 December 2020

A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase

1 reference

12 December 2020

Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase

1 reference

12 December 2020

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: tertiary amides

1 reference

12 December 2020

Non-nucleoside inhibitors of the HCV NS5B polymerase: progress in the discovery and development of novel agents for the treatment of HCV infections.

1 reference

12 December 2020

Comparison of HCV NS3 protease and NS5B polymerase inhibitor activity in 1a, 1b and 2a replicons and 2a infectious virus

1 reference

12 December 2020

Potentiating effect of ribavirin on the anti-herpes activity of acyclovir

1 reference

12 December 2020

Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines

1 reference

12 December 2020

Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

1 reference

12 December 2020

Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase

1 reference

12 December 2020

Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring.

1 reference

12 December 2020

Ribavirin and mycophenolic acid potentiate the activity of guanine- and diaminopurine-based nucleoside analogues against hepatitis B virus.

1 reference

12 December 2020

Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors

1 reference

12 December 2020

Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid.

1 reference

12 December 2020

Use of the yellow fever virus vaccine strain 17D for the study of strategies for the treatment of yellow fever virus infections.

1 reference

12 December 2020

Synthesis of BILN 2061, an HCV NS3 protease inhibitor with proven antiviral effect in humans

1 reference

12 December 2020

Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site

1 reference

12 December 2020

Novel nonnucleoside inhibitor of hepatitis C virus RNA-dependent RNA polymerase

1 reference

12 December 2020

Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: further optimization of anti-hepatitis C virus activity

1 reference

12 December 2020

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication

1 reference

12 December 2020

Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors

1 reference

12 December 2020

Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bio

1 reference

12 December 2020

Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine Inhibitor

1 reference

12 December 2020

Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle

1 reference

12 December 2020

Comparative activities of several nucleoside analogs against influenza A, B, and C viruses in vitro

1 reference

12 December 2020

Broad-spectrum antiviral activity and mechanism of antiviral action of the fluoroquinolone derivative K-12.

1 reference

12 December 2020

Selection of Replicon Variants Resistant to ACH-806, a Novel Hepatitis C Virus Inhibitor with No Cross-Resistance to NS3 Protease and NS5B Polymerase Inhibitors

1 reference

12 December 2020

Novel inhibitors of hepatitis C virus RNA-dependent RNA polymerases

1 reference

12 December 2020

Antiviral therapy for chronic hepatitis C: past, present, and future

1 reference

12 December 2020

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

1 reference

12 December 2020

Selective inhibitors of hepatitis C virus replication

1 reference

12 December 2020

1 reference

12 December 2020

Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.

1 reference

12 December 2020

Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase

1 reference

12 December 2020

Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109.

1 reference

12 December 2020

Challenges and successes in developing new therapies for hepatitis C.

1 reference

12 December 2020

Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid

1 reference

12 December 2020

3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase

1 reference

12 December 2020

Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

1 reference

12 December 2020

Emerging drugs for hepatitis C

1 reference

12 December 2020

A three-dimensional model to analyze drug-drug interactions

1 reference

12 December 2020

Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: from anti-pestivirus to anti-hepatitis C virus activity

1 reference

12 December 2020

Molecular Mechanism of a Thumb Domain Hepatitis C Virus Nonnucleoside RNA-Dependent RNA Polymerase Inhibitor

1 reference

12 December 2020

Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors

1 reference

12 December 2020

Hepatitis C virus (HCV) infection: a systemic disease.

1 reference

12 December 2020

A replicon-based bioassay for the measurement of interferons in patients with chronic hepatitis C.

1 reference

12 December 2020

Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro

1 reference

12 December 2020

Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection

1 reference

12 December 2020

Dissecting the interferon-induced inhibition of hepatitis C virus replication by using a novel host cell line

1 reference

12 December 2020

Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin

1 reference

12 December 2020

Cross-resistance testing of antihepadnaviral compounds using novel recombinant baculoviruses which encode drug-resistant strains of hepatitis B virus

1 reference

12 December 2020

Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase

1 reference

12 December 2020

Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase

1 reference

12 December 2020

Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase.

1 reference

12 December 2020

Finger loop inhibitors of the HCV NS5B polymerase: discovery and prospects for new HCV therapy

1 reference

12 December 2020

Ribavirin antagonizes the effect of azidothymidine on HIV replication

1 reference

12 December 2020

Antiviral activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4- carboxamide and related compounds

1 reference

12 December 2020

Identification of the thymidine kinase gene of feline herpesvirus: use of degenerate oligonucleotides in the polymerase chain reaction to isolate herpesvirus gene homologs

1 reference

12 December 2020

"I'll never touch it again, doctor!"--harmful drinking after liver transplantation

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12 December 2020

10.1016/J.JHEP.2008.12.028

Identifiers

DOI

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15 September 2017

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