(Q39878770)

English

Inhibition of cyclin-dependent kinases by olomoucine and roscovitine reduces lipopolysaccharide-induced inflammatory responses via down-regulation of nuclear factor kappaB.

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scholarly article

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Europe PubMed Central

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22 January 2020

Inhibition of cyclin-dependent kinases by olomoucine and roscovitine reduces lipopolysaccharide-induced inflammatory responses via down-regulation of nuclear factor kappaB (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19250292%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

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lipopolysaccharide

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5

1 reference

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14 May 2020

author name string

R-S Jhou

1

1 reference

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14 May 2020

K-H Sun

2

1 reference

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14 May 2020

G-H Sun

3

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14 May 2020

H-H Wang

4

1 reference

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14 May 2020

H-C Huang

6

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14 May 2020

S-Y Lu

7

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14 May 2020

S-J Tang

8

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14 May 2020

publication date

24 February 2009

1 reference

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22 January 2020

Cell Proliferation

1 reference

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14 May 2020

42

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14 May 2020

2

1 reference

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14 May 2020

141-149

1 reference

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14 May 2020

R-Roscovitine simultaneously targets both the p53 and NF-kappaB pathways and causes potentiation of apoptosis: implications in cancer therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal macrophages: unique effector cells of the innate immune system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The specificities of protein kinase inhibitors: an update

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a nuclear factor kappa B-dependent gene network

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappaB: linking inflammation and immunity to cancer development and progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Designing inhibitors of cyclin-dependent kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A revised picture of the E2F transcriptional network and RB function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between cell cycle regulator, E2F-1, and NF-kappaB mediates repression of HIV-1 gene transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

E2F-1 is essential for normal epidermal wound repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase (CDK) inhibitor olomoucine enhances gamma-irradiation-induced apoptosis and cell cycle arrest in Raji cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent advances in cyclin-dependent kinase inhibition. Purine-based derivatives as anti-cancer agents. Roles and perspectives for the future

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis of sepsis: new concepts and implications for future treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LPS induction of gene expression in human monocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappaB upon TLR4 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of astroglial scar formation and enhanced axonal regeneration associated with functional recovery in a spinal cord injury rat model by the cell cycle inhibitor olomoucine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic inflammation promotes retinoblastoma protein hyperphosphorylation and E2F1 activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipopolysaccharide endotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutics targeting the innate immune system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

E2F and cell cycle control: a double-edged sword

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survival-promoting activity of inhibitors of cyclin-dependent kinases on primary neurons correlates with inhibition of c-Jun kinase-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19250292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2184.2009.00584.X

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496709&resulttype=core&format=json

14 May 2020

release_xat2dcapxvh2rlcnyim5rjf6jy

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496709&resulttype=core&format=json

14 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496709&resulttype=core&format=json

14 May 2020

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