(Q39886267)

15 September 2017

title

Monitoring mammalian target of rapamycin (mTOR) activity (English)

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15 September 2017

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Tsuneo Ikenoue

1

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15 September 2017

Sungki Hong

series ordinal

2

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15 September 2017

Ken Inoki

series ordinal

3

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15 September 2017

language of work or name

English

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publication date

1 January 2009

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15 September 2017

published in

Methods in Enzymology

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15 September 2017

volume

452

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15 September 2017

page(s)

165-180

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https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

15 September 2017

1 reference

7 January 2021

The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

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https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

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https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

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https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

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https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

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https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Rheb binds and regulates the mTOR kinase

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https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

FoxO3 controls autophagy in skeletal muscle in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Autophagy fights disease through cellular self-digestion

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https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Contribution of Atg1-dependent autophagy to TOR-mediated cell growth and survival.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

mTOR and cancer: insights into a complex relationship

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https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Identification of a conserved motif required for mTOR signaling

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https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

TOR, a central controller of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

TOR signaling in growth and metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2903611-2

7 January 2021

10.1016/S0076-6879(08)03611-2

Identifiers

DOI

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release_z2cib4rfqzgfblaz2a2fscufcm

15 September 2017

Fatcat ID

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