(Q39942098)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18778245%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

title

Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18778245%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

0 references

2

1 reference

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13 January 2020

C Wolf

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18778245%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

author name string

Robert D Finn

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18778245%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Claire L Scott

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18778245%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

language of work or name

English

0 references

publication date

1 January 2009

1 reference

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13 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18778245%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

volume

417

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18778245%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18778245%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

page(s)

43-54

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18778245%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial 2.5 Generic

13 January 2020

copyright license

start time

25 July 2019

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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22 September 2017

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Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis

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22 September 2017

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A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway

22 September 2017

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Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype

22 September 2017

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AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

22 September 2017

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Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes

22 September 2017

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Disruption of hepatic lipid homeostasis in mice after amiodarone treatment is associated with peroxisome proliferator-activated receptor-alpha target gene activation

22 September 2017

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A human and mouse pregnane X receptor reporter gene assay in combination with cytotoxicity measurements as a tool to evaluate species-specific CYP3A induction

22 September 2017

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Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

22 September 2017

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Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase

22 September 2017

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Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

22 September 2017

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Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

22 September 2017

1 reference

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Cytochrome-P450 phosphorylation as a functional switch

22 September 2017

1 reference

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

22 September 2017

1 reference

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Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

22 September 2017

1 reference

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Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

22 September 2017

1 reference

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Regulation of cytochrome P450 (CYP) genes by nuclear receptors.

22 September 2017

1 reference

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The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

22 September 2017

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The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

22 September 2017

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

22 September 2017

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A keratinocyte-specific epoxygenase, CYP2B12, metabolizes arachidonic acid with unusual selectivity, producing a single major epoxyeicosatrienoic acid

22 September 2017

1 reference

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

22 September 2017

1 reference

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Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

22 September 2017

1 reference

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Dissection of NADPH-cytochrome P450 oxidoreductase into distinct functional domains

22 September 2017

1 reference

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A novel drug-regulated gene expression system based on the nuclear receptor constitutive androstane receptor (CAR).

22 September 2017

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The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

25 September 2017

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Cytochrome P450 3A conjugation to ubiquitin in a process distinct from classical ubiquitination pathway

25 September 2017

1 reference

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Modulation of murine phenobarbital-inducible CYP2A5, CYP2B10 and CYP1A enzymes by inhibitors of protein kinases and phosphatases

17 June 2018

1 reference

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Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes

17 June 2018

1 reference

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Zonation of hepatic cytochrome P-450 expression and regulation

17 June 2018

1 reference

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Characterization, localization and regulation of a novel phenobarbital-inducible form of cytochrome P450, compared with three further P450-isoenzymes, NADPH P450-reductase, glutathione transferases and microsomal epoxide hydrolase.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605957

Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605957

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605957

The repressor protein, Bm3R1, mediates an adaptive response to toxic fatty acids in Bacillus megaterium

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605957

PPARalpha-dependent induction of the energy homeostasis-regulating nuclear receptor NR1i3 (CAR) in rat hepatocytes: potential role in starvation adaptation

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605957

Changes in the expression of cytochromes P450 and nuclear receptors in the liver of genetically diabetic db/db mice.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605957

n-6 and n-3 polyunsaturated fatty acids down-regulate cytochrome P-450 2B1 gene expression induced by phenobarbital in primary rat hepatocytes

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605957

Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605957

Peroxisome proliferator-activated receptor alpha is required for feedback regulation of highly unsaturated fatty acid synthesis

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605957

Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605957

The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605957

The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605957

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605957

Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605957

Regulatory gene product of the Ah locus. Characterization of the cytosolic inducer-receptor complex and evidence for its nuclear translocation

20 August 2018

1 reference

12 December 2020

Epoxidation of unsaturated fatty acids by a soluble cytochrome P-450-dependent system from Bacillus megaterium

1 reference

12 December 2020

Phenobarbital induction of a soluble cytochrome P-450-dependent fatty acid monooxygenase in Bacillus megaterium

1 reference

12 December 2020

Induction of the hepatic mixed-function oxidase system by synthetic glucocorticoids. Transcriptional and post-transcriptional regulation

1 reference

12 December 2020

Hepatic CYP3A expression is attenuated in obese mice fed a high-fat diet

1 reference

12 December 2020

Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: a new model for studying the functions of the P450 system

1 reference

12 December 2020

Effects of bacterial lipopolysaccharide on phenobarbital-induced CYP2B expression in mice

1 reference

12 December 2020

Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice

1 reference

12 December 2020

Identifiers

DOI

10.1042/BJ20080740

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18778245%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18778245%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

PubMed publication ID

18778245

1 reference