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BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
2562222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723481%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
title
BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
2562222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723481%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
main subject
apoptotic process
0 references
cholangiocarcinoma
0 references
author
Justin L. Mott
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
2562222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723481%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
Scott H Kaufmann
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4
1 reference
stated in
Europe PubMed Central
PMC publication ID
2562222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723481%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
Gregory J Gores
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5
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Gregory J Gores
1 reference
stated in
Europe PubMed Central
PMC publication ID
2562222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723481%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
author name string
Steve F Bronk
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2
1 reference
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Europe PubMed Central
PMC publication ID
2562222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723481%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
Ruben A Mesa
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
2562222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723481%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
publication date
1 August 2008
1 reference
stated in
Europe PubMed Central
PMC publication ID
2562222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723481%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
published in
Molecular Cancer Therapeutics
1 reference
stated in
Europe PubMed Central
PMC publication ID
2562222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723481%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
volume
7
1 reference
stated in
Europe PubMed Central
PMC publication ID
2562222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723481%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
issue
8
1 reference
stated in
Europe PubMed Central
PMC publication ID
2562222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723481%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
page(s)
2339-2347
1 reference
stated in
Europe PubMed Central
PMC publication ID
2562222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723481%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
cites work
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Tumor necrosis factor-related apoptosis-inducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small cell lung cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
mir-29 regulates Mcl-1 protein expression and apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
A stapled BID BH3 helix directly binds and activates BAX
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Apoptosis in the treatment of cancer: a promise kept?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Interrelated roles for Mcl-1 and BIM in regulation of TRAIL-mediated mitochondrial apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Modulating the bcl-2 family of apoptosis suppressors for potential therapeutic benefit in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Life in the balance: how BH3-only proteins induce apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Mcl-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Biliary tract cancers.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Conformation of the Bax C-terminus regulates subcellular location and cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
What is synergy?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
22 September 2017
Establishment of a new extrahepatic bile duct carcinoma cell line, TFK-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
25 September 2017
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
15 June 2018
Establishment and characterization of a human combined hepatocholangiocarcinoma cell line and its heterologous transplantation in nude mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
15 June 2018
Establishment and characterization of a new human extrahepatic bile duct carcinoma cell line (KMBC)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
15 June 2018
Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
20 August 2018
TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
20 August 2018
Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
20 August 2018
The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2562222
retrieved
2 December 2018
Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18723481
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Restoring cancer's death sentence
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18723481
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18723481
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Functional linkage between NOXA and Bim in mitochondrial apoptotic events
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18723481
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1158/1535-7163.MCT-08-0285
1 reference
stated in
Europe PubMed Central
PMC publication ID
2562222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723481%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
Fatcat ID
release_fv55kg7oczei5j2cy6fya52cwi
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Fatcat
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https://api.fatcat.wiki/v0/release/fv55kg7oczei5j2cy6fya52cwi
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
PMC publication ID
2562222
1 reference
stated in
Europe PubMed Central
PMC publication ID
2562222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723481%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
PubMed publication ID
18723481
1 reference
stated in
Europe PubMed Central
PMC publication ID
2562222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723481%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
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