(Q39986126)

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The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18452078%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18452078%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

apoptotic process

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6 January 2020

1

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6 January 2020

Sandra Marmiroli

2

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6 January 2020

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6 January 2020

Jessika Bertacchini

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6 January 2020

Massimo Federico

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6 January 2020

Massimo Federico

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6 January 2020

12

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6 January 2020

Pierfrancesco Tassone

3

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Pierfrancesco Tassone

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6 January 2020

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Luigia Lombardi

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6 January 2020

Donata Verdelli

6

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6 January 2020

Monica Civallero

7

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6 January 2020

Maria Cosenza

8

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6 January 2020

Giorgio Lambertenghi Deliliers

13

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6 January 2020

publication date

1 July 2008

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6 January 2020

Leukemia & Lymphoma

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6 January 2020

49

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6 January 2020

7

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6 January 2020

1374-1383

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6 January 2020

Genetics and cytogenetics of multiple myeloma: a workshop report

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Insulin-like growth factor induces the survival and proliferation of myeloma cells through an interleukin-6-independent transduction pathway

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Novel biological therapies for the treatment of multiple myeloma

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Growth factors and antiapoptotic signaling pathways in multiple myeloma

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Protein kinase C inhibitors as novel anticancer drugs

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Calpha in endothelial cells

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Signal transduction pathways that contribute to myeloid differentiation

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patients

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

The AKT kinase is activated in multiple myeloma tumor cells

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Antiangiogenic effects of a protein kinase Cbeta-selective small molecule

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

The selective protein kinase C beta inhibitor enzastaurin induces apoptosis in cutaneous T-cell lymphoma cell lines through the AKT pathway

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Enzastaurin (LY317615), a protein kinase Cbeta inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl).

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

1 reference

https://api.crossref.org/works/10.1080%2F10428190802078289

21 January 2018

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