(Q40082372)

17 September 2017

title

MDM2 chaperones the p53 tumor suppressor (English)

1 reference

17 September 2017

0 references

1

Bartosz Wawrzynow

1 reference

17 September 2017

5

Maciej Zylicz

1 reference

17 September 2017

2

Alicja Zylicz

1 reference

17 September 2017

Maura Wallace

3

1 reference

17 September 2017

Ted Hupp

series ordinal

4

1 reference

17 September 2017

language of work or name

English

0 references

publication date

11 September 2007

1 reference

Journal of Biological Chemistry

17 September 2017

published in

1 reference

17 September 2017

volume

282

1 reference

17 September 2017

issue

45

1 reference

17 September 2017

page(s)

32603-32612

1 reference

17 September 2017

cites work

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

The p53 and Mdm2 families in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Functional regulation of p73 and p63: development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

The p53-Mdm2 module and the ubiquitin system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Intrasteric regulation of MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

21 January 2018

MDM2: life without p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

p53-independent activities of MDM2 and their relevance to cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Mdm2: A regulator of cell growth and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Genomic organisation of the human MDM2 oncogene and relationship to its alternatively spliced mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

MDM2 and MDMX bind and stabilize the p53-related protein p73

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Stimulation of human DNA polymerase epsilon by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Molecular chaperones in the cytosol: from nascent chain to folded protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Hsp90 chaperones wild-type p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Human p53 phosphorylation mimic, S392E, increases nonspecific DNA affinity and thermal stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Small peptides activate the latent sequence-specific DNA binding function of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Structure-function-rescue: the diverse nature of common p53 cancer mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Hsp70 interactions with the p53 tumour suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

p53 transcriptional activation domain: a molecular chameleon?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Temperature-dependent switching between "wild-type" and "mutant" forms of p53-Val135.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Global unfolding of a substrate protein by the Hsp100 chaperone ClpA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

The central region of HDM2 provides a second binding site for p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Mouse double minute 2 associates with chromatin in the presence of p53 and is released to facilitate activation of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Protein disaggregation mediated by heat-shock protein Hsp104.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

A molecular chaperone, ClpA, functions like DnaK and DnaJ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

The Clp ATPases define a novel class of molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

From the cradle to the grave: molecular chaperones that may choose between folding and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Protein quality control: U-box-containing E3 ubiquitin ligases join the fold

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Chaperone functions of the E3 ubiquitin ligase CHIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

The ubiquitin-proteasome system regulates p53-mediated transcription at p21waf1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702767200

21 January 2018

Identifiers

DOI

10.1074/JBC.M702767200

1 reference

17 September 2017

1 reference