(Q40082401)

English

Suppressor mutations in the transmembrane segments of P-glycoprotein promote maturation of processing mutants and disrupt a subset of drug-binding sites.

scientific article published on 11 September 2007

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17848563%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Suppressor mutations in the transmembrane segments of P-glycoprotein promote maturation of processing mutants and disrupt a subset of drug-binding sites (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17848563%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

transmembrane protein

0 references

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17848563%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

author name string

M Claire Bartlett

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17848563%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

David M Clarke

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17848563%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

language of work or name

0 references

publication date

11 September 2007

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17848563%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Journal of Biological Chemistry

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17848563%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

282

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17848563%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

44

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17848563%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

32043-32052

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17848563%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Disease-related misassembly of membrane proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

ER-associated and proteasomemediated protein degradation: how two topologically restricted events came together

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

About a switch: how P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

A primer on the mechanics of P-glycoprotein the multidrug transporter.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

P-glycoprotein substrate binding domains are located at the transmembrane domain/transmembrane domain interfaces: a combined photoaffinity labeling-protein homology modeling approach

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: evidence for simultaneous binding of both drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Insertion of an arginine residue into the transmembrane segments corrects protein misfolding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

A "silent" polymorphism in the MDR1 gene changes substrate specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Quality control by proteases in the endoplasmic reticulum. Removal of a protease-sensitive site enhances expression of human P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Folding of CFTR is predominantly cotranslational

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Permanent Activation of the Human P-glycoprotein by Covalent Modification of a Residue in the Drug-binding Site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Membrane topology of a cysteine-less mutant of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Additive effect of multiple pharmacological chaperones on maturation of CFTR processing mutants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Crystal structure of the transcription activator BmrR bound to DNA and a drug

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Structural mechanisms of QacR induction and multidrug recognition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Structural basis for ligand promiscuity in cytochrome P450 3A4.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

The drug-binding pocket of the human multidrug resistance P-glycoprotein is accessible to the aqueous medium.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Mutational Analysis of the Predicted First Transmembrane Segment of Each Homologous Half of Human P-glycoprotein Suggests That They Are Symmetrically Arranged in the Membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Modulating the Folding of P-Glycoprotein and Cystic Fibrosis Transmembrane Conductance Regulator Truncation Mutants with Pharmacological Chaperones

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Amino acid substitutions in the first transmembrane domain (TM1) of P-glycoprotein that alter substrate specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706175200

21 January 2018

Identifiers

10.1074/JBC.M706175200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17848563%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17848563%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q40082401&oldid=1483106962"