(Q40652649)

22 September 2017

title

Permanent activation of the human P-glycoprotein by covalent modification of a residue in the drug-binding site (English)

1 reference

22 September 2017

Permanent Activation of the Human P-glycoprotein by Covalent Modification of a Residue in the Drug-binding Site (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.C300154200

27 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.C300154200

27 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.C300154200

27 December 2023

1

Tip W. Loo

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12711602

27 December 2023

author name string

M. Claire Bartlett

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12711602

27 December 2023

David M. Clarke

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12711602

27 December 2023

language of work or name

English

0 references

publication date

23 April 2003

1 reference

full work available at URL

22 September 2017

http://www.jbc.org/content/278/23/20449.full.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12711602

https://api.elsevier.com/content/article/PII:S0021925820733351?httpAccept=text/xml

27 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.C300154200

https://api.elsevier.com/content/article/PII:S0021925820733351?httpAccept=text/plain

27 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.C300154200

https://syndication.highwire.org/content/doi/10.1074/jbc.C300154200

27 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.C300154200

Journal of Biological Chemistry

27 December 2023

published in

1 reference

22 September 2017

volume

278

1 reference

22 September 2017

issue

23

1 reference

22 September 2017

page(s)

20449-20452

1 reference

Mammalian ABC transporters in health and disease

22 September 2017

cites work

1 reference

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Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance

21 January 2018

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Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs

21 January 2018

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HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

21 January 2018

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Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

21 January 2018

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Membrane topology of a cysteine-less mutant of human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300154200

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300154200

Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

21 January 2018

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The minimum functional unit of human P-glycoprotein appears to be a monomer.

21 January 2018

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The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

21 January 2018

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Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

21 January 2018

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ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR.

21 January 2018

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Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

21 January 2018

1 reference

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Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers

21 January 2018

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Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.

21 January 2018

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Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

21 January 2018

1 reference

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Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.

21 January 2018

1 reference

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Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

21 January 2018

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Novel sulfhydryl reagents

21 January 2018

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Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

21 January 2018

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Drug binding in human P-glycoprotein causes conformational changes in both nucleotide-binding domains.

21 January 2018

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A single amino acid residue contributes to distinct mechanisms of inhibition of the human multidrug transporter by stereoisomers of the dopamine receptor antagonist flupentixol.

21 January 2018

1 reference

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P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic Site

21 January 2018

1 reference

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The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence

21 January 2018

1 reference

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Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding.

21 January 2018

1 reference

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Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300154200

Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300154200

Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes

21 January 2018

1 reference

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Short and long range functions of amino acids in the transmembrane region of the sarcoplasmic reticulum ATPase. A mutational study

21 January 2018

1 reference

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Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300154200

Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300154200

Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300154200

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300154200

Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300154200

ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

21 January 2018

13

1 reference

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A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: application to lens ATPases

27 December 2023

27

1 reference

https://api.crossref.org/works/10.1074/JBC.C300154200

Myosin active-site trapping with vanadate ion

27 December 2023

28

1 reference

https://api.crossref.org/works/10.1074/JBC.C300154200

Relationships of molecular structure and function in Ca2(+)-transport ATPase

27 December 2023

43

1 reference

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27 December 2023

Identifiers

1 reference

22 September 2017

1 reference