(Q40085533)

17 September 2017

title

Cellular oligomerization of alpha-synuclein is determined by the interaction of oxidized catechols with a C-terminal sequence (English)

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17 September 2017

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Joseph R Mazzulli

1

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17 September 2017

Maria Armakola

2

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17 September 2017

Michelle Dumoulin

3

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17 September 2017

Ioannis Parastatidis

4

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17 September 2017

Harry Ischiropoulos

5

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17 September 2017

language of work or name

English

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publication date

4 September 2007

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Journal of Biological Chemistry

17 September 2017

published in

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17 September 2017

volume

282

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17 September 2017

issue

43

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17 September 2017

page(s)

31621-31630

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

17 September 2017

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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alpha-Synuclein locus triplication causes Parkinson's disease

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Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein

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Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.

21 January 2018

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Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications

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Dopamine covalently modifies and functionally inactivates parkin

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Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

21 January 2018

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Dopamine and L-dopa disaggregate amyloid fibrils: implications for Parkinson's and Alzheimer's disease

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21 January 2018

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Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.

21 January 2018

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A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

21 January 2018

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Pro-thrombotic state induced by post-translational modification of fibrinogen by reactive nitrogen species.

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Alpha-crystallin can function as a molecular chaperone

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Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.

21 January 2018

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The mutation of two amino acid residues in the N-terminus of tyrosine hydroxylase (TH) dramatically enhances the catalytic activity in neuroendocrine AtT-20 cells

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Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections

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Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

21 January 2018

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Role of alpha-synuclein carboxy-terminus on fibril formation in vitro

21 January 2018

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Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

21 January 2018

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A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease

21 January 2018

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Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein

21 January 2018

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Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

21 January 2018

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Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.

21 January 2018

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Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

21 January 2018

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Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation.

21 January 2018

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Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration

21 January 2018

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Parkinson's disease and dementia with Lewy bodies: a difference in dose?

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M704737200

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17 September 2017

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