(Q40093022)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17703234%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

title

Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1/Noxa axis and gradual exhaustion of Bcl-2 protection (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17703234%20AND%20SRC:MED&resulttype=core&format=json

B-cell chronic lymphocytic leukemia

3 January 2020

main subject

1 reference

2

1 reference

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3 January 2020

Nuno L. Alves

5

1 reference

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3 January 2020

Felix M Wensveen

6

1 reference

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3 January 2020

author name string

D Y H Hallaert

1

1 reference

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3 January 2020

M Jak

3

1 reference

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3 January 2020

I A M Derks

4

1 reference

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3 January 2020

J P de Boer

7

1 reference

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3 January 2020

D de Jong

8

1 reference

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3 January 2020

S R Green

9

1 reference

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3 January 2020

M H J van Oers

10

1 reference

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3 January 2020

E Eldering

11

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3 January 2020

publication date

17 August 2007

1 reference

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Cell Death & Differentiation

3 January 2020

published in

1 reference

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3 January 2020

volume

14

1 reference

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3 January 2020

issue

11

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3 January 2020

page(s)

1958-1967

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4402211

3 January 2020

exact match

0 references

cites work

Chronic Lymphocytic Leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

The role of BH3-only proteins in the immune system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Chronic lymphocytic leukemia cells display p53-dependent drug-induced Puma upregulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

PUMA, a novel proapoptotic gene, is induced by p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

PUMA induces the rapid apoptosis of colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukaemia cells following their culture in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Endogenous association of Bim BH3-only protein with Mcl-1, Bcl-xL and Bcl-2 on mitochondria in human B cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

CD20-induced B cell death can bypass mitochondria and caspase activation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Movement of Bax from the cytosol to mitochondria during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Inhibition of Bax channel-forming activity by Bcl-2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Functional linkage between NOXA and Bim in mitochondrial apoptotic events

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Apoptosis via the B cell antigen receptor requires Bax translocation and involves mitochondrial depolarization, cytochrome C release, and caspase-9 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402211

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4402211

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17703234%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

3 January 2020

1032385416

0 references

1 reference