(Q40097101)

17 September 2017

title

Hypophosphorylated TCR/CD3zeta signals through a Grb2-SOS1-Ras pathway in Lck knockdown cells (English)

1 reference

17 September 2017

Kjetil Taskén

5

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author name string

Trond Methi

1

1 reference

17 September 2017

Jacob Ngai

2

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17 September 2017

Torkel Vang

3

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17 September 2017

Knut M Torgersen

4

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17 September 2017

language of work or name

English

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publication date

1 September 2007

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European Journal of Immunology

17 September 2017

published in

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17 September 2017

volume

37

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17 September 2017

issue

9

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17 September 2017

page(s)

2539-2548

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The epidermal growth factor receptor phosphorylates GTPase-activating protein (GAP) at Tyr-460, adjacent to the GAP SH2 domains

17 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

Lck is required for activation-induced T cell death after TCR ligation with partial agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

Superantigen stimulation reveals the contribution of Lck to negative regulation of T cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

Short-interfering RNA-mediated Lck knockdown results in augmented downstream T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

Protein tyrosine phosphorylation in T cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Proximal protein tyrosine kinases in immunoreceptor signaling

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

T-cell receptor signal transmission: who gives an ITAM?

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Adaptors as central mediators of signal transduction in immune cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Mitogen-activated protein kinase cascades and regulation of gene expression

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Ras GTPase-activating protein: a substrate and a potential binding protein of the protein-tyrosine kinase p56lck

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Bacterial Superantigens Bypass Lck-Dependent T Cell Receptor Signaling by Activating a Gα11-Dependent, PLC-β-Mediated Pathway

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Zap-70-independent Ca(2+) mobilization and Erk activation in Jurkat T cells in response to T-cell antigen receptor ligation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

A comparison of the interaction of Shc and the tyrosine kinase ZAP-70 with the T cell antigen receptor zeta chain tyrosine-based activation motif

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Differential and multiple binding of signal transducing molecules to the ITAMs of the TCR-zeta chain

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Profound block in thymocyte development in mice lacking p56lck

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

The CD3 gamma epsilon/delta epsilon signaling module provides normal T cell functions in the absence of the TCR zeta immunoreceptor tyrosine-based activation motifs

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Partially phosphorylated T cell receptor zeta molecules can inhibit T cell activation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Qualitatively differential regulation of T cell activation and apoptosis by T cell receptor zeta chain ITAMs and their tyrosine residues.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

The tyrosine kinase Lck is a positive regulator of the mitochondrial apoptosis pathway by controlling Bak expression

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

HIV Nef increases T cell ERK MAP kinase activity.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200636973

7 January 2021

Identifiers

DOI

10.1002/EJI.200636973

1 reference

17 September 2017

1 reference