(Q24317331)

positive regulation of intrinsic apoptotic signaling pathway

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

A K Samraj

1

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C Stroh

2

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U Fischer

3

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K Schulze-Osthoff

Inhibition of Bax channel-forming activity by Bcl-2

4

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language of work or name

English

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publication date

12 January 2006

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published in

Oncogene

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volume

25

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page(s)

186-97

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issue

2

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cites work

1 reference

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alpha-Toxin is a mediator of Staphylococcus aureus-induced cell death and activates caspases via the intrinsic death pathway independently of death receptor signaling

21 January 2018

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The role of STATs in apoptosis

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The tyrosine kinase lck is required for CD95-independent caspase-8 activation and apoptosis in response to ionizing radiation.

21 January 2018

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Nonredundant role of Bax and Bak in Bid-mediated apoptosis

21 January 2018

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Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines

21 January 2018

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The Bcl-2 family: roles in cell survival and oncogenesis.

21 January 2018

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Guardians of cell death: the Bcl-2 family proteins

21 January 2018

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Cellular survival: a play in three Akts

21 January 2018

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BAX and BAK mediate p53-independent suppression of tumorigenesis

21 January 2018

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The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling

21 January 2018

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Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

21 January 2018

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

21 January 2018

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Staphylococcus aureus alpha-toxin-induced cell death: predominant necrosis despite apoptotic caspase activation

21 January 2018

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Organelle-specific initiation of cell death pathways

21 January 2018

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LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway

21 January 2018

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Many cuts to ruin: a comprehensive update of caspase substrates

21 January 2018

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Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway

21 January 2018

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Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

21 January 2018

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Involvement of tyrosine kinase p56/Lck in apoptosis induction by anticancer drugs

21 January 2018

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Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

21 January 2018

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The Src kinase Lyn is a negative regulator of mast cell proliferation

21 January 2018

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Rosmarinic acid induces p56lck-dependent apoptosis in Jurkat and peripheral T cells via mitochondrial pathway independent from Fas/Fas ligand interaction

21 January 2018

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Signal transduction by the TCR for antigen

21 January 2018

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Bcl-X(L) specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum

21 January 2018

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

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Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis

21 January 2018

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Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin

21 January 2018

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Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release

21 January 2018

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Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin.

21 January 2018

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Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis

21 January 2018

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Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

21 January 2018

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Distinctive functions of Syk and Lyn in mediating osmotic stress- and ultraviolet C irradiation-induced apoptosis in chicken B cells.

21 January 2018

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Apoptosis signaling by death receptors.

21 January 2018

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Non-apoptotic functions of caspases in cellular proliferation and differentiation

21 January 2018

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Regulation of apoptosis by alternative pre-mRNA splicing

21 January 2018

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Herbimycin A induces the 20 S proteasome- and ubiquitin-dependent degradation of receptor tyrosine kinases

21 January 2018

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Control of T cell function by positive and negative regulators

21 January 2018

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Oncogenic tyrosine kinases and the DNA-damage response

21 January 2018

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Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209034

Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209034

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

21 January 2018

1 reference

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Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis

21 January 2018

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BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells

21 January 2018

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Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209034

A role for mitochondrial Bak in apoptotic response to anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209034

v-Src generates a p53-independent apoptotic signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209034

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209034

Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209034

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209034

Movement of Bax from the cytosol to mitochondria during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209034

The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209034

Long-Term Survival But Impaired Homeostatic Proliferation of Naive T Cells in the Absence of p56lck

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209034

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209034

Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209034

7 January 2021

A matter of life and death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209034

7 January 2021

Bak but not Bax is essential for Bcl-xS-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209034

7 January 2021

Protein tyrosine kinase p56lck is required for ceramide-induced but not tumor necrosis factor-induced activation of NF-kappa B, AP-1, JNK, and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209034

7 January 2021