(Q73731212)

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Protein tyrosine kinase p56lck is required for ceramide-induced but not tumor necrosis factor-induced activation of NF-kappa B, AP-1, JNK, and apoptosis

scientific article published on 01 May 2000

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10788436%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

Protein tyrosine kinase p56lck is required for ceramide-induced but not tumor necrosis factor-induced activation of NF-kappa B, AP-1, JNK, and apoptosis (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10788436%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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S K Manna

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10788436%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

N K Sah

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10788436%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

B B Aggarwal

3

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Europe PubMed Central

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6 November 2019

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1 May 2000

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6 November 2019

Journal of Biological Chemistry

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10788436%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

275

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6 November 2019

18

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6 November 2019

13297-13306

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10788436%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

Functions of ceramide in coordinating cellular responses to stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Involvement of protein kinase C-beta and ceramide in tumor necrosis factor-alpha-induced but not Fas-induced apoptosis of human myeloid leukemia cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

A novel pathway for tumor necrosis factor-alpha and ceramide signaling involving sequential activation of tyrosine kinase, p21(ras), and phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Ceramide-induced nuclear translocation of NF-kappa B is a potential mediator of the apoptotic response to TNF-alpha in murine clonal osteoblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Ceramide does not mediate the effect of tumour necrosis factor alpha on superoxide generation in human neutrophils

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Relationships of apoptotic signaling mediated by ceramide and TNF-alpha in U937 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Tumor necrosis factor induces ceramide oscillations and negatively controls sphingolipid synthases by caspases in apoptotic Kym-1 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Analysis of human breast adenocarcinoma MCF7 resistance to tumor necrosis factor-induced cell death. Lack of correlation between JNK activation and ceramide pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Alteration of the sphingomyelin/ceramide pathway is associated with resistance of human breast carcinoma MCF7 cells to tumor necrosis factor-alpha-mediated cytotoxicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Endothelial cell inflammatory responses to tumor necrosis factor alpha. Ceramide-dependent and -independent mitogen-activated protein kinase cascades

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

A single base mutation in the 5' splice site of intron 7 of the lck gene is responsible for the deletion of exon 7 in lck mRNA of the JCaM1 cell line

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Activators and target genes of Rel/NF-kappaB transcription factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Differential IκB Kinase Activation and IκBα Degradation by Interleukin-1β and Tumor Necrosis Factor-α in Human U937 Monocytic Cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

AP-1 function and regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alpha.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

TNF-induced signaling in apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Site-specific tyrosine phosphorylation of IkappaBalpha negatively regulates its inducible phosphorylation and degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

L-selectin activates JNK via src-like tyrosine kinases and the small G-protein Rac

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Oxidative stress as a mediator of apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Overexpression of gamma-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

The activated form of the Lck tyrosine protein kinase in cells exposed to hydrogen peroxide is phosphorylated at both Tyr-394 and Tyr-505

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

The tyrosine kinase lck is required for CD95-independent caspase-8 activation and apoptosis in response to ionizing radiation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Cell-cycle arrest and apoptosis hypersusceptibility as a consequence of Lck deficiency in nontransformed T lymphocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.18.13297

21 January 2018

Identifiers

10.1074/JBC.275.18.13297

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10788436%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10788436%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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