(Q40143247)

English

Metal specificity of an iron-responsive element in Alzheimer's APP mRNA 5'untranslated region, tolerance of SH-SY5Y and H4 neural cells to desferrioxamine, clioquinol, VK-28, and a piperazine chelator.

scientific article published on January 2006

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29 December 2019

Metal specificity of an iron-responsive element in Alzheimer's APP mRNA 5'untranslated region, tolerance of SH-SY5Y and H4 neural cells to desferrioxamine, clioquinol, VK-28, and a piperazine chelator (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17447434%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Alzheimer's disease

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Sanghamitra Bandyopadhyay

1

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29 December 2019

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X Huang

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29 December 2019

H Cho

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29 December 2019

N H Greig

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29 December 2019

M B Youdim

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29 December 2019

J T Rogers

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29 December 2019

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1 January 2006

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29 December 2019

Journal of neural transmission. Supplementum

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29 December 2019

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29 December 2019

237-247

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29 December 2019

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1 reference

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31 March 2020

In vivo evaluation of brain iron in Alzheimer disease using magnetic resonance imaging

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Mitochondria, Oxidative Damage, and Inflammation in Parkinson's Disease

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Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene

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The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons.

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The oxidative neurotoxicity of clioquinol

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Deferiprone versus desferrioxamine in thalassaemia, and T2* validation and utility.

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Metal complexing agents as therapies for Alzheimer's disease

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The metallobiology of Alzheimer's disease

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Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines

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Overexpression of superoxide dismutase 1 protects against beta-amyloid peptide toxicity: effect of estrogen and copper chelators

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31 March 2020

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

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31 March 2020

The 5′-Untranslated Region of Human Transferrin mRNA, Which Contains a Putative Iron-Regulatory Element, Is Bound by Purified Iron-Regulatory Protein in a Sequence-Specific Manner

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31 March 2020

Intramuscular desferrioxamine in patients with Alzheimer's disease

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31 March 2020

Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

1 reference

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31 March 2020

IRP1 Ser-711 is a phosphorylation site, critical for regulation of RNA-binding and aconitase activities.

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31 March 2020

Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion

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31 March 2020

Iron-dependent regulation of the divalent metal ion transporter

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31 March 2020

Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver

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31 March 2020

Oxygen toxicity, oxygen radicals, transition metals and disease

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31 March 2020

Hemin and related porphyrins inhibit beta-amyloid aggregation

1 reference

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31 March 2020

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

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31 March 2020

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

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31 March 2020

Assessing p97 as an Alzheimer's disease serum biomarker.

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31 March 2020

Brain iron and ferritin in Parkinson's and Alzheimer's diseases.

1 reference

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31 March 2020

Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

1 reference

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31 March 2020

Iron accumulation during cellular senescence

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31 March 2020

Regulating the fate of mRNA: the control of cellular iron metabolism

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31 March 2020

Effects of ICL670 (deferasirox) on cardiac iron concentrations

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31 March 2020

Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1.

1 reference

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31 March 2020

Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice

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31 March 2020

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

1 reference

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Copper, iron and zinc in Alzheimer's disease senile plaques.

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Expression of thrombospondins in skeletal muscle

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A GG nucleotide sequence of the 3' untranslated region of amyloid precursor protein mRNA plays a key role in the regulation of translation and the binding of proteins

1 reference

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31 March 2020

A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation

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31 March 2020

Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model

1 reference

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31 March 2020

Drug Discovery Targeted to the Alzheimer's APP mRNA 5'-Untranslated Region: The Action of Paroxetine and Dimercaptopropanol

1 reference

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In vivo reduction of amyloid-beta by a mutant copper transporter

1 reference

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31 March 2020

Porphyrin and phthalocyanine antiscrapie compounds.

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Growth factor-mediated stabilization of amyloid precursor protein mRNA is mediated by a conserved 29-nucleotide sequence in the 3'-untranslated region

1 reference

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31 March 2020

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

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Metal and inflammatory targets for Alzheimer's disease

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31 March 2020

Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences.

1 reference

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An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

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Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region.

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The hemochromatosis gene affects the age of onset of sporadic Alzheimer's disease.

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Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats

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Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease

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Widespread peroxynitrite-mediated damage in Alzheimer's disease.

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Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease

1 reference

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Oxidative-stress associated parameters (lactoferrin, superoxide dismutases) in serum of patients with Alzheimer's disease.

1 reference

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Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress.

1 reference

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The acute box cis-element in human heavy ferritin mRNA 5'-untranslated region is a unique translation enhancer that binds poly(C)-binding proteins

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p97 as a biomarker for Alzheimer disease

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The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region

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Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

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The iron chelating cardioprotective prodrug dexrazoxane does not affect the cell growth inhibitory effects of bleomycin

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Identifiers

10.1007/978-3-211-33328-0_25

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17447434%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17447434%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

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