(Q40146627)

English

Apolipoprotein receptor 2 and X11 alpha/beta mediate apolipoprotein E-induced endocytosis of amyloid-beta precursor protein and beta-secretase, leading to amyloid-beta production

scientific article published on April 2007

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scholarly article

1 reference

Europe PubMed Central

17 September 2017

Apolipoprotein receptor 2 and X11 alpha/beta mediate apolipoprotein E-induced endocytosis of amyloid-beta precursor protein and beta-secretase, leading to amyloid-beta production (English)

1 reference

Europe PubMed Central

17 September 2017

author name string

Xiangyuan He

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672528&resulttype=core&format=json

16 May 2020

Kathleen Cooley

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672528&resulttype=core&format=json

16 May 2020

Charlotte H Y Chung

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672528&resulttype=core&format=json

16 May 2020

Nassrin Dashti

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672528&resulttype=core&format=json

16 May 2020

Jordan Tang

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672528&resulttype=core&format=json

16 May 2020

language of work or name

0 references

publication date

1 April 2007

1 reference

Europe PubMed Central

17 September 2017

Journal of Neuroscience

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672528&resulttype=core&format=json

16 May 2020

27

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672528&resulttype=core&format=json

16 May 2020

15

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672528&resulttype=core&format=json

16 May 2020

4052-4060

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672528&resulttype=core&format=json

16 May 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6672528/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reelin is a ligand for lipoprotein receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein interaction mapping in C. elegans using proteins involved in vulval development

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation regulates intracellular trafficking of beta-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta).

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: the cholesterol connection

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP processing and synaptic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol and the biology of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein B-containing lipoprotein particle assembly: lipid capacity of the nascent lipoprotein particle

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clearance of Alzheimer's Abeta peptide: the many roads to perdition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E and Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of APP secretion by apolipoprotein E3 and E4

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/17428983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3993-06.2007

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672528&resulttype=core&format=json

16 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672528&resulttype=core&format=json

16 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672528&resulttype=core&format=json

16 May 2020

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