(Q40147932)

17 September 2017

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title

The Soluble Interleukin 6 Receptor: Advanced Therapeutic Options in Inflammation (English)

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17 September 2017

Stefan Rose-John

1

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language of work or name

English

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publication date

4 July 2017

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Clinical Pharmacology & Therapeutics

17 September 2017

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17 September 2017

102

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17 September 2017

591-598

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17 September 2017

4

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IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6.

17 September 2017

1 reference

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

21 January 2018

1 reference

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells

21 January 2018

1 reference

Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts

21 January 2018

1 reference

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

21 January 2018

1 reference

Interleukin-6: Biology, signaling and strategies of blockade

21 January 2018

1 reference

The pro- and anti-inflammatory properties of the cytokine interleukin-6.

21 January 2018

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The three carboxy-terminal amino acids of human interleukin-6 are essential for its biological activity

21 January 2018

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The soluble interleukin-6 receptor is generated by shedding

21 January 2018

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Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor.

21 January 2018

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Molecular cloning of mouse protein kinase C (PKC) cDNA from Swiss 3T3 fibroblasts.

21 January 2018

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Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)

21 January 2018

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Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation

21 January 2018

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Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17.

21 January 2018

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Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor

21 January 2018

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Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles

21 January 2018

1 reference

Soluble receptors for cytokines and growth factors: generation and biological function

21 January 2018

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The soluble interleukin-6 receptor and related proteins

21 January 2018

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Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells.

21 January 2018

1 reference

IL-6 biology: implications for clinical targeting in rheumatic disease

21 January 2018

1 reference

Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor

21 January 2018

1 reference

Interleukin-6 and neural stem cells: more than gliogenesis

21 January 2018

1 reference

Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells

21 January 2018

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Maintenance of pluripotency in human embryonic stem cells is STAT3 independent

21 January 2018

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Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses

21 January 2018

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Transgenic blockade of interleukin 6 transsignaling abrogates inflammation

21 January 2018

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The role of interleukin-6 signaling in nervous tissue

21 January 2018

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Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells

21 January 2018

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GP130 activation induces myeloma and collaborates with MYC.

21 January 2018

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Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice

21 January 2018

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The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition

21 January 2018

1 reference

The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome

21 January 2018

1 reference

The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.

21 January 2018

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Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases

21 January 2018

1 reference

A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy.

21 January 2018

1 reference

The role of IL-6 in host defence against infections: immunobiology and clinical implications

21 January 2018

1 reference

Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial

21 January 2018

1 reference

Design of effective immunotherapy for human autoimmunity

21 January 2018

1 reference

IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling

21 January 2018

1 reference

Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor

21 January 2018

1 reference

STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice

21 January 2018

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The role of IL-6 trans-signaling in vascular leakage: implications for ovarian hyperstimulation syndrome in a murine model

21 January 2018

1 reference

The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.

21 January 2018

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Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation.

21 January 2018

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IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3.

21 January 2018

1 reference

Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN.

21 January 2018

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IL-6 Trans-Signaling Drives Murine Crescentic GN

21 January 2018

1 reference

Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance

21 January 2018

1 reference

IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer

21 January 2018

1 reference

IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality

21 January 2018

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IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis.

21 January 2018

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IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice.

21 January 2018

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Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema.

21 January 2018

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IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

21 January 2018

1 reference

Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model

21 January 2018

1 reference

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

21 January 2018

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Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model*

21 January 2018

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Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis

21 January 2018

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Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the Brain

21 January 2018

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Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils

21 January 2018

1 reference

7 January 2021

Studies on the structure and regulation of the human hepatic interleukin-6 receptor

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7 January 2021

A bioactive designer cytokine for human hematopoietic progenitor cell expansion

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7 January 2021

Ligand/Receptor Signaling Threshold (LIST) Model Accounts for gp130-Mediated Embryonic Stem Cell Self-Renewal Responses to LIF and HIL-6

1 reference

7 January 2021

The interleukin 6 pathway and atherosclerosis

1 reference

7 January 2021

TNF antagonists opened the way to personalized medicine in rheumatoid arthritis

1 reference

7 January 2021

Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis

1 reference

7 January 2021

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

1 reference

7 January 2021

Inhibition of IL-6 signaling significantly reduces primary tumor growth and recurrencies in orthotopic xenograft models of pancreatic cancer

1 reference

7 January 2021

Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130

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7 January 2021

Transsignaling of Interleukin-6 Crucially Contributes to Atherosclerosis in Mice

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7 January 2021

Identifiers

DOI

10.1002/CPT.782

1 reference

17 September 2017

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PubMed ID

28675418