(Q40150370)

21 February 2018

title

Ultra-sensitive Sequencing Identifies High Prevalence of Clonal Hematopoiesis-Associated Mutations throughout Adult Life (English)

1 reference

21 February 2018

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6

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21 February 2018

Joris A Veltman

object named as

Joris A Veltman

7

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Alexander Hoischen

9

object named as

Alexander Hoischen

1 reference

21 February 2018

Rocio Acuna-Hidalgo

1

1 reference

21 February 2018

Hilal Sengul

2

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21 February 2018

Marloes Steehouwer

3

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21 February 2018

Maartje van de Vorst

4

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21 February 2018

Sita H Vermeulen

5

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21 February 2018

Christian Gilissen

8

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21 February 2018

language of work or name

English

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publication date

19 June 2017

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21 February 2018

American Journal of Human Genetics

published in

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21 February 2018

volume

101

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21 February 2018

issue

1

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21 February 2018

page(s)

50-64

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21 February 2018

Pathogenic ASXL1 somatic variants in reference databases complicate germline variant interpretation for Bohring-Opitz Syndrome

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DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification.

15 June 2018

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Preleukaemic clonal haemopoiesis and risk of therapy-related myeloid neoplasms: a case-control study

15 June 2018

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Novel BRCA1 and BRCA2 Tumor Test as Basis for Treatment Decisions and Referral for Genetic Counselling of Patients with Ovarian Carcinomas

15 June 2018

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Reliable Next-Generation Sequencing of Formalin-Fixed, Paraffin-Embedded Tissue Using Single Molecule Tags

15 June 2018

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Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

15 June 2018

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Aging of hematopoietic stem cells: DNA damage and mutations?

15 June 2018

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Aging, Clonality, and Rejuvenation of Hematopoietic Stem Cells

15 June 2018

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Coming of age: ten years of next-generation sequencing technologies

15 June 2018

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The landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selection

15 June 2018

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Visualizing the origins of selfish de novo mutations in individual seminiferous tubules of human testes.

15 June 2018

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Interpreting the Dependence of Mutation Rates on Age and Time

15 June 2018

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Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance

15 June 2018

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15 June 2018

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Clock-like mutational processes in human somatic cells

15 June 2018

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Aging, clonal hematopoiesis and preleukemia: not just bad luck?

15 June 2018

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Aging as a driver of leukemogenesis

15 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations

15 June 2018

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Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis

15 June 2018

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DNMT3A in haematological malignancies

15 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Genetic diagnosis of developmental disorders in the DDD study: a scalable analysis of genome-wide research data

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

MIPgen: optimized modeling and design of molecular inversion probes for targeted resequencing

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Prioritization of neurodevelopmental disease genes by discovery of new mutations

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Age-dependent germline mosaicism of the most common noonan syndrome mutation shows the signature of germline selection

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

The ageing haematopoietic stem cell compartment

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Single molecule molecular inversion probes for targeted, high-accuracy detection of low-frequency variation

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Positive selection for new disease mutations in the human germline: evidence from the heritable cancer syndrome multiple endocrine neoplasia type 2B

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Patterns of somatic mutation in human cancer genomes

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

BRCA Testing by Single-Molecule Molecular Inversion Probes

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Insights into cell ontogeny, age, and acute myeloid leukemia

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Contributions of intrinsic mutation rate and selfish selection to levels of de novo HRAS mutations in the paternal germline

17 June 2018

1 reference

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Cohort Profile: The Nijmegen Biomedical Study (NBS).

17 June 2018

1 reference

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Acute myeloid leukemia-associated DNMT3A p.Arg882His mutation in a patient with Tatton-Brown-Rahman overgrowth syndrome as a constitutional mutation.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

'CHIP'ping away at clonal hematopoiesis.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Analysis of 589,306 genomes identifies individuals resilient to severe Mendelian childhood diseases.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

De novo nonsense mutations in ASXL1 cause Bohring-Opitz syndrome

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Germline mutation in BRAF codon 600 is compatible with human development: de novo p.V600G mutation identified in a patient with CFC syndrome

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

Two Novel Methods for Rapid Detection and Quantification of DNMT3A R882 Mutations in Acute Myeloid Leukemia

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5501773

10.1016/J.AJHG.2017.05.013

2 December 2018

Identifiers

DOI

1 reference

21 February 2018

PMC publication ID

5501773

1 reference

21 February 2018

PubMed publication ID

28669404

1 reference

21 February 2018