(Q40177137)

English

Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans

scientific article published on October 2004

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans (English)

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Christian Vaisse

7

object named as

Christian Vaisse

0 references

author name string

Supriya Srinivasan

1

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Cecile Lubrano-Berthelier

2

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Cedric Govaerts

3

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Franck Picard

4

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Pamela Santiago

5

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Bruce R Conklin

6

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Christian Vaisse

7

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

language of work or name

0 references

publication date

1 October 2004

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Europe PubMed Central

PMC publication ID

18 September 2017

Journal of Clinical Investigation

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Europe PubMed Central

PMC publication ID

18 September 2017

114

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

8

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

1158-1164

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Protease-activated receptors: new concepts in regulation of G protein-coupled receptor signaling and trafficking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Engineering the melanocortin-4 receptor to control G(s) signaling in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Molecular genetics of human obesity-associated MC4R mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Poor Cell Surface Expression of Human Melanocortin-4 Receptor Mutations Associated with Obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Genetic approaches to studying energy balance: perception and integration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

The role of melanocortins in body weight regulation: opportunities for the treatment of obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Molecular determinants of ligand binding to the human melanocortin-4 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Functional characterization of mutations in melanocortin-4 receptor associated with human obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin,

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Characterization of Agouti-related protein binding to melanocortin receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

A frameshift mutation in human MC4R is associated with a dominant form of obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Deletions of the N-terminal regions of the human melanocortin receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Molecular cloning, expression, and gene localization of a fourth melanocortin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

22 September 2017

Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

25 September 2017

Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

25 September 2017

AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

25 September 2017

Lack of proopiomelanocortin peptides results in obesity and defective adrenal function but normal melanocyte pigmentation in the murine C57BL/6 genetic background

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

17 June 2018

A ligand-mimetic model for constitutive activation of the melanocortin-1 receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

17 June 2018

Neuroscience. The fat-brain axis enters a new dimension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

20 August 2018

The human MC4R promoter: characterization and role in obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

20 August 2018

Kinetics of thyrotropin-stimulating hormone (TSH) and thyroid-stimulating antibody binding and action on the TSH receptor in intact TSH receptor-expressing CHO cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

20 August 2018

Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

20 August 2018

Is the energy homeostasis system inherently biased toward weight gain?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

20 August 2018

A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

20 August 2018

Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

20 August 2018

A leptin missense mutation associated with hypogonadism and morbid obesity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

20 August 2018

Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=522250

20 August 2018

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/15489963

12 December 2020

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Identifiers

10.1172/JCI21927

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

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