(Q40205378)

18 September 2017

title

Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation (English)

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18 September 2017

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8

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18 September 2017

Hirotsugu Kamei

1

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18 September 2017

Taro Saito

2

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18 September 2017

Mirai Ozawa

3

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18 September 2017

Yuichi Fujita

4

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18 September 2017

Akiko Asada

5

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18 September 2017

James A Bibb

6

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18 September 2017

Takaomi C Saido

7

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18 September 2017

Shin-Ichi Hisanaga

9

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18 September 2017

language of work or name

English

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publication date

22 November 2006

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Journal of Biological Chemistry

18 September 2017

published in

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18 September 2017

volume

282

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18 September 2017

issue

3

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18 September 2017

page(s)

1687-1694

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https://api.crossref.org/works/10.1074%2FJBC.M610541200

18 September 2017

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The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Glycogen synthase kinase 3: a drug target for CNS therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Cdk5, a therapeutic target for Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Neurotoxicity induces cleavage of p35 to p25 by calpain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Cdk5 is a key factor in tau aggregation and tangle formation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Cdk5 phosphorylates p53 and regulates its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Structure, activation, and biology of calpain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Dephosphorylation of neurofilament proteins enhances their susceptibility to degradation by calpain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Src-mediated tyrosine phosphorylation of NR2 subunits of N-methyl-D-aspartate receptors protects from calpain-mediated truncation of their C-terminal domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

PKA-mediated protein phosphorylation protects ezrin from calpain I cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Activation of μ-calpain in developing cortical neurons following methylmercury treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Phosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

A brain-specific activator of cyclin-dependent kinase 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

On the sequential determinants of calpain cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Structure and regulation of the CDK5-p25(nck5a) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Identification of the calmodulin-binding domain of neuron-specific protein kinase C substrate protein CAP-22/NAP-22. Direct involvement of protein myristoylation in calmodulin-target protein interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Cloning of three novel neuronal Cdk5 activator binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Precursor of cdk5 activator, the 23 kDa subunit of tau protein kinase II: its sequence and developmental change in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

Activation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610541200

21 January 2018

Identifiers

DOI

10.1074/JBC.M610541200

1 reference

release_u7ndd2lizfdizj6furi6vmdro4

18 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/u7ndd2lizfdizj6furi6vmdro4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference