(Q40211477)

18 September 2017

title

Need for tripeptidyl-peptidase II in major histocompatibility complex class I viral antigen processing when proteasomes are detrimental (English)

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18 September 2017

Luis C Antón

5

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Margarita del Val

object named as

Margarita Del Val

6

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author name string

Sara Guil

1

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18 September 2017

Marta Rodríguez-Castro

2

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18 September 2017

Francisco Aguilar

3

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18 September 2017

Eugenia M Villasevil

4

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18 September 2017

language of work or name

English

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publication date

6 November 2006

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Journal of Biological Chemistry

18 September 2017

published in

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18 September 2017

volume

281

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18 September 2017

issue

52

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18 September 2017

page(s)

39925-39934

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Protein degradation and protection against misfolded or damaged proteins

18 September 2017

cites work

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The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases.

21 January 2018

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Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation

21 January 2018

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ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

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An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides

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21 January 2018

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21 January 2018

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Major histocompatibility complex class I viral antigen processing in the secretory pathway defined by the trans-Golgi network protease furin.

21 January 2018

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Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation

21 January 2018

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21 January 2018

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Sequential cleavage by metallopeptidases and proteasomes is involved in processing HIV-1 ENV epitope for endogenous MHC class I antigen presentation

21 January 2018

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21 January 2018

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21 January 2018

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Purification and characterisation of a tripeptidyl aminopeptidase I from rat spleen

21 January 2018

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Rapid degradation of a large fraction of newly synthesized proteins by proteasomes.

21 January 2018

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An endogenous HIV envelope-derived peptide without the terminal NH3+ group anchor is physiologically presented by major histocompatibility complex class I molecules

21 January 2018

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The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues

21 January 2018

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A proteolytic system that compensates for loss of proteasome function

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M608522200

1 reference

18 September 2017

1 reference