(Q40308550)

19 September 2017

title

A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity (English)

1 reference

19 September 2017

Yuri K Peterson

1

1 reference

19 September 2017

Patrick Kelly

series ordinal

2

1 reference

19 September 2017

Carolyn A Weinbaum

series ordinal

3

1 reference

19 September 2017

Patrick J Casey

series ordinal

4

1 reference

19 September 2017

language of work or name

English

0 references

publication date

3 March 2006

1 reference

Journal of Biological Chemistry

19 September 2017

published in

1 reference

19 September 2017

volume

281

1 reference

19 September 2017

issue

18

1 reference

19 September 2017

page(s)

12445-12450

1 reference

Protein prenylation: molecular mechanisms and functional consequences

19 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Farnesyltransferase inhibitors: promises and realities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Protein prenyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

The role of Rho GTPases in disease development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Targeting signal transduction for disease therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Prenylation inhibitors: a novel class of antiviral agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Tetrapeptide inhibitors of protein farnesyltransferase: amino-terminal substitution in phenylalanine-containing tetrapeptides restores farnesylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

RNA interference (RNAi) in hematology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Synergistic cytotoxic effects in myeloid leukemia cells upon cotreatment with farnesyltransferase and geranylgeranyl transferase-I inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Kinetics of protein farnesyltransferase: sigmoidal vs hyperbolic behavior as a function of assay conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

A rho exchange factor mediates thrombin and Galpha(12)-induced cytoskeletal responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Selective uncoupling of G alpha 12 from Rho-mediated signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Heterotrimeric G-protein betagamma-dimers in growth and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

21 January 2018

RHO-GTPases and cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Rho GTPases and the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Rho family proteins and Ras transformation: the RHOad less traveled gets congested.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Rho GTPases: potential candidates for anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Modulating angiogenesis: more vs less

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600168200

21 January 2018

Identifiers

DOI

10.1074/JBC.M600168200

1 reference

release_7fjvq62ya5bmhgxen6j6w6c4ty

19 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7fjvq62ya5bmhgxen6j6w6c4ty

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference