(Q40318210)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16470212%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Modification of the p53 transgene of a replication-competent adenovirus prevents mdm2- and E1b-55kD-mediated degradation of p53 (English)

1 reference

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16 January 2020

1 reference

1

1 reference

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16 January 2020

John G Hay

8

1 reference

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16 January 2020

author name string

T Pipiya

2

1 reference

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16 January 2020

S Chen

3

1 reference

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16 January 2020

S Heitner

4

1 reference

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16 January 2020

J Cheng

5

1 reference

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16 January 2020

Y Q Huang

6

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16 January 2020

W N Rom

7

1 reference

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16 January 2020

language of work or name

1 reference

10 February 2006

1 reference

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16 January 2020

1 reference

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16 January 2020

volume

13

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16 January 2020

issue

7

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16 January 2020

page(s)

686-695

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Live or let die: the cell's response to p53

16 January 2020

cites work

1 reference

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21 January 2018

Surfing the p53 network

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Expression of exogenous wt-p53 does not affect normal hematopoiesis: implications for bone marrow purging.

21 January 2018

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Adenovirus-mediated delivery of p53 results in substantial apoptosis to myeloma cells and is not cytotoxic to flow-sorted CD34(+) hematopoietic progenitor cells and normal lymphocytes

21 January 2018

1 reference

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Adenovirus-mediated wild-type p53 gene expression radiosensitizes non-small cell lung cancer cells but not normal lung fibroblasts

21 January 2018

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A phase I study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer

21 January 2018

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Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results

21 January 2018

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A phase I/II trial of rAd/p53 (SCH 58500) gene replacement in recurrent ovarian cancer

21 January 2018

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Repeated intravesical instillations of an adenoviral vector in patients with locally advanced bladder cancer: a phase I study of p53 gene therapy

21 January 2018

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Why did p53 gene therapy fail in ovarian cancer?

21 January 2018

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Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: results of a multicenter phase II study

21 January 2018

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Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer

21 January 2018

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a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

21 January 2018

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Regulation of p53 stability by Mdm2

21 January 2018

1 reference

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Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

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Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas

21 January 2018

1 reference

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Control of p53 expression by adenovirus 12 early region 1A and early region 1B 54K proteins

21 January 2018

1 reference

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Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700936

Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery

21 January 2018

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

21 January 2018

1 reference

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Deletion of the adenoviral E1b-19kD gene enhances tumor cell killing of a replicating adenoviral vector

21 January 2018

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Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: virus persists and spreads systemically at late time points

21 January 2018

1 reference

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Sequestration of p53 in the cytoplasm by adenovirus type 12 E1B 55-kilodalton oncoprotein is required for inhibition of p53-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700936

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700936

Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700936

Regulation of p53 stability and function in HCT116 colon cancer cells

21 January 2018

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Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

21 January 2018

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An E1B-19 kDa gene deletion mutant adenovirus demonstrates tumor necrosis factor-enhanced cancer selectivity and enhanced oncolytic potency

21 January 2018

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Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700936

E1B-55-kilodalton protein is not required to block p53-induced transcription during adenovirus infection

21 January 2018

1 reference

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Binding and modulation of p53 by p300/CBP coactivators

21 January 2018

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The therapeutic efficacy of adenoviral vectors for cancer gene therapy is limited by a low level of primary adenovirus receptors on tumour cells

21 January 2018

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Hypoxia reduces adenoviral replication in cancer cells by downregulation of viral protein expression

21 January 2018

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Tumor-specific, replication-competent adenovirus vectors overexpressing the adenovirus death protein

21 January 2018

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A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases.

21 January 2018

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Adenoviral vectors capable of replication improve the efficacy of HSVtk/GCV suicide gene therapy of cancer

21 January 2018

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Inclusion of the herpes simplex thymidine kinase gene in a replicating adenovirus does not augment antitumor efficacy

21 January 2018

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Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen.

21 January 2018

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Gene delivery from the E3 region of replicating human adenovirus: evaluation of the E3B region

21 January 2018

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Gene delivery from the E3 region of replicating human adenovirus: evaluation of the ADP region

21 January 2018

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Oncolytic activity of p53-expressing conditionally replicative adenovirus AdDelta24-p53 against human malignant glioma

21 January 2018

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Safety evaluation of Ad5CMV-p53 in vitro and in vivo

21 January 2018

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7 January 2021

Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700936

7 January 2021

Wild-type adenovirus decreases tumor xenograft growth, but despite viral persistence complete tumor responses are rarely achieved--deletion of the viral E1b-19-kD gene increases the viral oncolytic effect

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700936

7 January 2021

Late expression of p53 from a replicating adenovirus improves tumor cell killing and is more tumor cell specific than expression of the adenoviral death protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700936

7 January 2021

Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.CGT.7700936

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16470212%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

16 January 2020

1046643323

0 references

1 reference