(Q40364273)

19 September 2017

title

Identification of inhibitors of the kinase activity of oncogenic V600E BRAF in an enzyme cascade high-throughput screen (English)

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19 September 2017

4

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10

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Caroline Springer

7

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Paul Workman

11

object named as

Paul Workman

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19 September 2017

Yvette Newbatt

1

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Samantha Burns

2

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Robert Hayward

3

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Ruth Kirk

5

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Christopher Marshall

6

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Edward McDonald

8

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Cancer Genome Project

9

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Wynne Aherne

12

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19 September 2017

publication date

16 December 2005

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Journal of Biomolecular Screening

19 September 2017

published in

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19 September 2017

volume

11

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19 September 2017

issue

2

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19 September 2017

page(s)

145-154

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Mitogen-activated protein kinase pathways

19 September 2017

cites work

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https://api.crossref.org/works/10.1177%2F1087057105283584

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Targeting the mitogen-activated protein kinase cascade to treat cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Discovering novel chemotherapeutic drugs for the third millennium

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Unraveling the complexities of the Raf/MAP kinase pathway for pharmacological intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Raf kinase as a target for anticancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Paradoxical activation of Raf by a novel Raf inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Discovery of a novel Raf kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

A synthetic inhibitor of the mitogen-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

A census of human cancer genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Mutations of the BRAF gene in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Guilty as charged: B-RAF is a human oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

V599EB-RAF is an oncogene in melanocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

B-RAF is a therapeutic target in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Improved statistical methods for hit selection in high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Finding the needle in the haystack: why high-throughput screening is good for your health

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Novel detection strategies for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

High-throughput screening for kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

A scintillation proximity assay for the Raf/MEK/ERK kinase cascade: high-throughput screening and identification of selective enzyme inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057105283584

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057105283584

[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057105283584

21 January 2018

Identifiers

DOI

10.1177/1087057105283584

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19 September 2017

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