(Q40399348)

English

Chronic activation of protein kinase Bbeta/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: events associated with tumorigenesis

scientific article published on August 2005

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scholarly article

1 reference

Europe PubMed Central

20 September 2017

Chronic activation of protein kinase Bbeta/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: events associated with tumorigenesis (English)

1 reference

Europe PubMed Central

20 September 2017

James R. Woodgett

2

1 reference

Europe PubMed Central

20 September 2017

author name string

Jing Jin

1

1 reference

Europe PubMed Central

20 September 2017

language of work or name

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publication date

1 August 2005

1 reference

Europe PubMed Central

20 September 2017

1 reference

Europe PubMed Central

20 September 2017

24

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Europe PubMed Central

20 September 2017

5459-5470

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Europe PubMed Central

20 September 2017

35

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Europe PubMed Central

20 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1208704

0 references

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

1 reference

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AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival

1 reference

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A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

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The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.

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Advances in protein kinase B signalling: AKTion on multiple fronts

1 reference

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

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The phosphoinositide 3-kinase pathway

1 reference

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AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

1 reference

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Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

1 reference

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Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa

1 reference

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

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Phosphatidylinositol 3-phosphate is generated in phagosomal membranes.

1 reference

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Overexpression of the human MNB/DYRK1A gene induces formation of multinucleate cells through overduplication of the centrosome

1 reference

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Role of phosphatidylinositol 3' kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in dictyostelium

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The centrosome-associated Aurora/Ipl-like kinase family

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The Hallmarks of Cancer

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Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

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Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion

1 reference

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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Regulation of Drosophila tracheal system development by protein kinase B.

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Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

1 reference

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A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

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Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers

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PDK1, the master regulator of AGC kinase signal transduction

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Polyploid Incidence and Evolution

1 reference

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Sequential activities of phosphoinositide 3-kinase, PKB/Aakt, and Rab7 during macropinosome formation in Dictyostelium

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Mycobacterium tuberculosis: here today, and here tomorrow

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Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation

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Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

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PKB/AKT: functional insights from genetic models

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A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

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Roles of PI3Ks in leukocyte chemotaxis and phagocytosis

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From polyploidy to aneuploidy, genome instability and cancer

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PTEN: from pathology to biology

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Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

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Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

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Mitotic kinase expression and colorectal cancer progression

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7 January 2021

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10.1038/SJ.ONC.1208704

1 reference

Europe PubMed Central

20 September 2017

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1 reference

Europe PubMed Central

20 September 2017

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