(Q40436587)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27927959%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

title

Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice (English)

1 reference

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29 March 2020

1

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29 March 2020

Lingzhi Zhao

2

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29 March 2020

Mayur S. Parmar

4

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29 March 2020

Man Ying Wong

5

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29 March 2020

Thomas Woo

6

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29 March 2020

Stephen M. Kaminsky

10

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29 March 2020

Steven M Paul

12

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29 March 2020

author name string

Brittany Blackman

3

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29 March 2020

Fangmin Yu

7

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29 March 2020

Maria J Chiuchiolo

8

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29 March 2020

Dolan Sondhi

9

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29 March 2020

Ronald G Crystal

11

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29 March 2020

language of work or name

English

0 references

publication date

1 December 2016

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29 March 2020

published in

Journal of Neuroscience

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29 March 2020

volume

36

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29 March 2020

issue

49

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29 March 2020

page(s)

12425-12435

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Alzheimer's disease: genes, proteins, and therapy

29 March 2020

cites work

1 reference

12 December 2020

Neurofibrillary pathology leads to synaptic loss and not the other way around in Alzheimer disease.

1 reference

12 December 2020

Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.

1 reference

12 December 2020

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

1 reference

12 December 2020

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1 reference

12 December 2020

Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins

1 reference

12 December 2020

Stereotaxic gene delivery in the rodent brain.

1 reference

12 December 2020

Neuropathological stageing of Alzheimer-related changes

1 reference

12 December 2020

Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection

1 reference

12 December 2020

The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments.

1 reference

12 December 2020

Efficient gene therapy-based method for the delivery of therapeutics to primate cortex

1 reference

12 December 2020

Transmission and spreading of tauopathy in transgenic mouse brain

1 reference

12 December 2020

AAV-mediated gene delivery in adult GM1-gangliosidosis mice corrects lysosomal storage in CNS and improves survival

1 reference

12 December 2020

Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model

1 reference

12 December 2020

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

1 reference

12 December 2020

Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease.

1 reference

12 December 2020

Therapeutic antibodies for brain disorders.

1 reference

12 December 2020

A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo

1 reference

12 December 2020

Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.

1 reference

12 December 2020

Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice

1 reference

12 December 2020

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

1 reference

12 December 2020

Biochemistry and cell biology of tau protein in neurofibrillary degeneration

1 reference

12 December 2020

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

1 reference

12 December 2020

Long-term expression and safety of administration of AAVrh.10hCLN2 to the brain of rats and nonhuman primates for the treatment of late infantile neuronal ceroid lipofuscinosis.

1 reference

12 December 2020

Tau passive immunotherapy in mutant P301L mice: antibody affinity versus specificity

1 reference

12 December 2020

Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

1 reference

12 December 2020

Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology

1 reference

12 December 2020

Antibody uptake into neurons occurs primarily via clathrin-dependent Fcγ receptor endocytosis and is a prerequisite for acute tau protein clearance.

1 reference

12 December 2020

Alzheimer disease therapy--moving from amyloid-β to tau.

1 reference

12 December 2020

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

1 reference

12 December 2020

Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease.

1 reference

12 December 2020

Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease.

1 reference

12 December 2020

Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging

1 reference

12 December 2020

Anti-tau antibody reduces insoluble tau and decreases brain atrophy

1 reference

12 December 2020

Tau immunotherapy for Alzheimer's disease

1 reference

12 December 2020

Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models

1 reference

12 December 2020

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.

1 reference

12 December 2020

Passive Immunization in JNPL3 Transgenic Mice Using an Array of Phospho-Tau Specific Antibodies

1 reference

12 December 2020

Clinical Improvement of Alpha-mannosidosis Cat Following a Single Cisterna Magna Infusion of AAV1.

1 reference

12 December 2020

Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells.

1 reference

12 December 2020

1 reference

12 December 2020

Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis

1 reference

12 December 2020

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

1 reference

12 December 2020

Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.

1 reference

12 December 2020

10.1523/JNEUROSCI.2016-16.2016

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27927959%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

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29 March 2020

PubMed publication ID

27927959

1 reference