(Q40497616)

21 September 2017

The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover (English)

1 reference

21 September 2017

R Hakem

11

0 references

Thomas Kislinger

object named as

T Kislinger

8

0 references

author name string

M Bohgaki

1

1 reference

21 September 2017

A Hakem

2

1 reference

21 September 2017

M J Halaby

3

1 reference

21 September 2017

T Bohgaki

4

1 reference

21 September 2017

Q Li

5

1 reference

21 September 2017

P A Bissey

6

1 reference

21 September 2017

J Shloush

7

1 reference

21 September 2017

O Sanchez

9

1 reference

21 September 2017

Y Sheng

10

1 reference

21 September 2017

1 March 2013

1 reference

Cell Death & Differentiation

21 September 2017

1 reference

21 September 2017

20

1 reference

21 September 2017

6

1 reference

21 September 2017

812-822

1 reference

The E3 ligase RNF8 regulates KU80 removal and NHEJ repair

21 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Role of Pirh2 in mediating the regulation of p53 and c-Myc

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

The spatial and temporal organization of ubiquitin networks

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Axin determines cell fate by controlling the p53 activation threshold after DNA damage

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Mdm2 and PCAF increase Chk2 ubiquitination and degradation independently of their intrinsic E3 ligase activities

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Molecular basis of Pirh2-mediated p53 ubiquitylation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Pirh2 interacts with and ubiquitylates signal recognition particle receptor beta subunit

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

The age of crosstalk: phosphorylation, ubiquitination, and beyond

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

The ubiquitin-specific protease USP28 is required for MYC stability

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

EDD mediates DNA damage-induced activation of CHK2

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Methods for studying the cellular response to DNA damage: influence of the Mre11 complex on chromosome metabolism.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

The BRCT Domain Is a Phospho-Protein Binding Domain

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Chk2 activation and phosphorylation-dependent oligomerization

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Characterization of tumor-associated Chk2 mutations

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

The E3 ubiquitin ligase EDD regulates S-phase and G(2)/M DNA damage checkpoints.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3647240

Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation

20 August 2018

1 reference

12 December 2020

Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours

1 reference

12 December 2020

Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome

1 reference

12 December 2020

Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA

1 reference

12 December 2020

Identifiers

DOI

10.1038/CDD.2013.7

1 reference

Dimensions Publication ID

21 September 2017

1008344134

0 references

Fatcat ID

release_kzbuiql7wndk5fotx3m6547tpq

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/kzbuiql7wndk5fotx3m6547tpq

24 November 2022

mapped directly with Wikidata item

1 reference

21 September 2017

PubMed publication ID

23449389

1 reference