(Q40090354)

17 September 2017

title

Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456. (English)

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17 September 2017

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6

Carol Prives

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17 September 2017

Elizabeth M Kass

1

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17 September 2017

Jinwoo Ahn

2

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17 September 2017

Tomoaki Tanaka

3

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17 September 2017

William A Freed-Pastor

4

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17 September 2017

Susan Keezer

5

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17 September 2017

language of work or name

English

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publication date

21 August 2007

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Journal of Biological Chemistry

17 September 2017

published in

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17 September 2017

volume

282

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17 September 2017

issue

41

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17 September 2017

page(s)

30311-30321

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The DNA damage response: putting checkpoints in perspective

17 September 2017

cites work

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21 January 2018

The Chk2 protein kinase

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Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation

21 January 2018

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The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation

21 January 2018

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Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis

21 January 2018

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The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

21 January 2018

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Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain.

21 January 2018

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p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.

21 January 2018

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

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CHK2-dependent phosphorylation of BRCA1 in hypoxia

21 January 2018

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Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining

21 January 2018

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Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

21 January 2018

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PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

21 January 2018

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Chk2 activates E2F-1 in response to DNA damage

21 January 2018

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Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.

21 January 2018

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ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

21 January 2018

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Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

21 January 2018

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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

21 January 2018

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Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain

21 January 2018

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21 January 2018

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Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2

21 January 2018

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Chk2 activation and phosphorylation-dependent oligomerization

21 January 2018

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Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

21 January 2018

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The BRCT Domain Is a Phospho-Protein Binding Domain

21 January 2018

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A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer

21 January 2018

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CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas

21 January 2018

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Chk1 and Chk2 kinases in checkpoint control and cancer

21 January 2018

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p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2.

21 January 2018

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Accurate mass-driven analysis for the characterization of protein phosphorylation. Study of the human Chk2 protein kinase.

21 January 2018

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Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange

21 January 2018

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Characterization of tumor-associated Chk2 mutations

21 January 2018

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A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

21 January 2018

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Inducible degradation of checkpoint kinase 2 links to cisplatin-induced resistance in ovarian cancer cells

21 January 2018

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The ubiquitin-specific protease USP28 is required for MYC stability

21 January 2018

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Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

21 January 2018

1 reference

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A phosphorylation-driven ubiquitination switch for cell-cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704642200

Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway.

21 January 2018

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Concomitant inactivation of p53 and Chk2 in breast cancer

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M704642200

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17 September 2017

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