(Q40648923)

English

Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN β‐cell line and human islets of Langerhans

scientific article published on May 8, 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

22 September 2017

Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN β‐cell line and human islets of Langerhans (English)

1 reference

10.1096/FJ.02-0685FJE

https://api.crossref.org/works/10.1096/FJ.02-0685FJE

31 December 2023

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signal transduction

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12738810

31 December 2023

1 reference

10.1096/FJ.02-0685FJE

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31 December 2023

1 reference

10.1096/FJ.02-0685FJE

https://api.crossref.org/works/10.1096/FJ.02-0685FJE

31 December 2023

1 reference

10.1096/FJ.02-0685FJE

https://api.crossref.org/works/10.1096/FJ.02-0685FJE

31 December 2023

3

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Sarah Lovari

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31 December 2023

Francesco Andreozzi

4

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Francesco Andreozzi

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31 December 2023

Antonio Brunetti

19

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Antonio Brunetti

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31 December 2023

20

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Franco Folli

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31 December 2023

author name string

Lucia Perego

2

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Europe PubMed Central

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22 September 2017

Rossella Menghini

5

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Europe PubMed Central

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22 September 2017

Carla Perego

6

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Europe PubMed Central

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22 September 2017

Giovanna Finzi

7

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Europe PubMed Central

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22 September 2017

Luciana Usellini

8

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Europe PubMed Central

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22 September 2017

Claudia Placidi

9

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Europe PubMed Central

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22 September 2017

Carlo Capella

10

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22 September 2017

Valeria Guzzi

11

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Europe PubMed Central

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22 September 2017

Davide Lauro

12

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22 September 2017

Federico Bertuzzi

13

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22 September 2017

Alberto Davalli

14

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22 September 2017

Guido Pozza

15

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22 September 2017

Antonio Pontiroli

16

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22 September 2017

Massimo Federici

17

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22 September 2017

Renato Lauro

18

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22 September 2017

Giorgio Sesti

21

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22 September 2017

Marta L. Hribal

1

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31 December 2023

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publication date

8 May 2003

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Europe PubMed Central

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22 September 2017

full work available at URL

http://www.fasebj.org/cgi/content/abstract/17/10/1340

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12738810

31 December 2023

https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.02-0685fje

1 reference

10.1096/FJ.02-0685FJE

https://api.crossref.org/works/10.1096/FJ.02-0685FJE

31 December 2023

https://onlinelibrary.wiley.com/doi/full-xml/10.1096/fj.02-0685fje

1 reference

10.1096/FJ.02-0685FJE

https://api.crossref.org/works/10.1096/FJ.02-0685FJE

31 December 2023

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

17

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

1340-1342

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Insulin signalling and the regulation of glucose and lipid metabolism

1

1 reference

10.1096/FJ.02-0685FJE

https://api.crossref.org/works/10.1096/FJ.02-0685FJE

31 December 2023

Glucose toxicity

2

1 reference

10.1096/FJ.02-0685FJE

https://api.crossref.org/works/10.1096/FJ.02-0685FJE

31 December 2023

Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function

3

1 reference

10.1096/FJ.02-0685FJE

https://api.crossref.org/works/10.1096/FJ.02-0685FJE

31 December 2023

High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

4

1 reference

10.1096/FJ.02-0685FJE

https://api.crossref.org/works/10.1096/FJ.02-0685FJE

31 December 2023

Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation

5

1 reference

10.1096/FJ.02-0685FJE

https://api.crossref.org/works/10.1096/FJ.02-0685FJE

31 December 2023

Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15

6

1 reference

10.1096/FJ.02-0685FJE

https://api.crossref.org/works/10.1096/FJ.02-0685FJE

31 December 2023

The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression

7

1 reference

10.1096/FJ.02-0685FJE

https://api.crossref.org/works/10.1096/FJ.02-0685FJE

31 December 2023

Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator

8

1 reference

10.1096/FJ.02-0685FJE

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31 December 2023

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

9

1 reference

10.1096/FJ.02-0685FJE

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31 December 2023

Endocrine pancreas in insulin receptor-deficient mouse pups

10

1 reference

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31 December 2023

Disruption of IRS-2 causes type 2 diabetes in mice

11

1 reference

10.1096/FJ.02-0685FJE

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31 December 2023

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

12

1 reference

10.1096/FJ.02-0685FJE

https://api.crossref.org/works/10.1096/FJ.02-0685FJE

31 December 2023

The common Arg972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets

13

1 reference

10.1096/FJ.02-0685FJE

https://api.crossref.org/works/10.1096/FJ.02-0685FJE

31 December 2023

The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells

14

1 reference

10.1096/FJ.02-0685FJE

https://api.crossref.org/works/10.1096/FJ.02-0685FJE

31 December 2023

Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways

15

1 reference

10.1096/FJ.02-0685FJE

https://api.crossref.org/works/10.1096/FJ.02-0685FJE

31 December 2023

Structure of the human insulin receptor gene and characterization of its promoter

16

1 reference

10.1096/FJ.02-0685FJE

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31 December 2023

Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells

18

1 reference

10.1096/FJ.02-0685FJE

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31 December 2023

Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action

19

1 reference

10.1096/FJ.02-0685FJE

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31 December 2023

Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells

20

1 reference

10.1096/FJ.02-0685FJE

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31 December 2023

Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects

21

1 reference

10.1096/FJ.02-0685FJE

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31 December 2023

Regulation of human insulin receptor RNA splicing in HepG2 cells: effects of glucocorticoid and low glucose concentration

22

1 reference

10.1096/FJ.02-0685FJE

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31 December 2023

Regulation of human insulin receptor RNA splicing in vivo

23

1 reference

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31 December 2023

Muscle cell differentiation is associated with increased insulin receptor biosynthesis and messenger RNA levels

26

1 reference

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31 December 2023

Transcriptional regulation of human insulin receptor gene by the high-mobility group protein HMGI(Y).

27

1 reference

10.1096/FJ.02-0685FJE

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31 December 2023

Tissue-specific expression of two alternatively spliced isoforms of the human insulin receptor protein.

28

1 reference

10.1096/FJ.02-0685FJE

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31 December 2023

Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes

29

1 reference

10.1096/FJ.02-0685FJE

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31 December 2023

Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose

31

1 reference

10.1096/FJ.02-0685FJE

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31 December 2023

Identification of unique nuclear regulatory proteins for the insulin receptor gene, which appear during myocyte and adipocyte differentiation

32

1 reference

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31 December 2023

PI3K: downstream AKTion blocks apoptosis

33

1 reference

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31 December 2023

Control of p70 s6 kinase by kinase activity of FRAP in vivo

34

1 reference

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31 December 2023

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

35

1 reference

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31 December 2023

Regulation of translation initiation by FRAP/mTOR

37

1 reference

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31 December 2023

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

38

1 reference

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31 December 2023

The trans-most cisternae of the Golgi complex: a compartment for sorting of secretory and plasma membrane proteins

39

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The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment

41

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31 December 2023

Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose

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31 December 2023

Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle.

45

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31 December 2023

Muscle fiber type specificity in insulin signal transduction

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Interleukin-6 induces cellular insulin resistance in hepatocytes

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Growth hormone induces cellular insulin resistance by uncoupling phosphatidylinositol 3-kinase and its downstream signals in 3T3-L1 adipocytes

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Insulin mediates glucose-stimulated phosphorylation of PHAS-I by pancreatic beta cells. An insulin-receptor mechanism for autoregulation of protein synthesis by translation

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Effects of prolonged glucose infusion on insulin secretion, clearance, and action in normal subjects

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31 December 2023

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10.1096/FJ.02-0685FJE

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

ResearchGate publication ID

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