(Q40665907)

22 September 2017

title

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer (English)

1 reference

22 September 2017

1 reference

11

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10 June 2020

Ian J Majewski

12

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10 June 2020

Manel Esteller

19

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10 June 2020

Edwin Cuppen

20

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10 June 2020

17

Frans Hogervorst

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10 June 2020

6

Esther Lips

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10 June 2020

author name string

Petra Ter Brugge

1

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10 June 2020

Petra Kristel

2

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10 June 2020

Eline van der Burg

3

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10 June 2020

Ute Boon

4

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10 June 2020

Michiel de Maaker

5

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10 June 2020

Lennart Mulder

7

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10 June 2020

Julian de Ruiter

8

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10 June 2020

Catia Moutinho

9

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10 June 2020

Heidrun Gevensleben

10

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10 June 2020

Katarzyna Józwiak

13

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10 June 2020

Wigard Kloosterman

14

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10 June 2020

Markus van Roosmalen

15

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10 June 2020

Karen Duran

16

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10 June 2020

Nick Turner

18

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10 June 2020

Jelle Wesseling

21

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10 June 2020

Jos Jonkers

22

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10 June 2020

language of work or name

English

0 references

publication date

5 July 2016

1 reference

Journal of the National Cancer Institute

22 September 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27381626%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

108

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10 June 2020

issue

11

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Triple-Negative Breast Cancer

10 June 2020

cites work

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Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens

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Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

21 January 2018

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Enhanced sensitivity to cisplatin and gemcitabine in Brca1-deficient murine mammary epithelial cells

21 January 2018

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21 January 2018

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Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer

21 January 2018

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BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells

21 January 2018

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Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy

21 January 2018

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Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer

21 January 2018

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Targeting the double-strand DNA break repair pathway as a therapeutic strategy

21 January 2018

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

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Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.

21 January 2018

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Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.

21 January 2018

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21 January 2018

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Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

21 January 2018

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Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2.

21 January 2018

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Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.

21 January 2018

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Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas.

21 January 2018

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Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

21 January 2018

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Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance

21 January 2018

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Resistance to therapy caused by intragenic deletion in BRCA2

21 January 2018

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A new model of patient tumor-derived breast cancer xenografts for preclinical assays

21 January 2018

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21 January 2018

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A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer

21 January 2018

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Human copper transporters: mechanism, role in human diseases and therapeutic potential

21 January 2018

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Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors

21 January 2018

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Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping.

21 January 2018

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21 January 2018

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21 January 2018

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Mapping the cellular and molecular heterogeneity of normal and malignant breast tissues and cultured cell lines

21 January 2018

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Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

21 January 2018

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A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models

21 January 2018

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21 January 2018

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21 January 2018

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Aberrant methylation of breast and ovarian cancer susceptibility gene 1 in chemosensitive human ovarian cancer cells does not involve the phosphatidylinositol 3'-kinase-Akt pathway

21 January 2018

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Gene rearrangement: a novel mechanism for MDR-1 gene activation

21 January 2018

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21 January 2018

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21 January 2018

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The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

21 January 2018

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BRCA1 CpG Island Hypermethylation Predicts Sensitivity to Poly(Adenosine Diphosphate)- Ribose Polymerase Inhibitors

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/JNCI/DJW148

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27381626%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference