(Q39616232)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21183737%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2 (English)

1 reference

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18 January 2020

12

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18 January 2020

9

Zdenek Hostomsky

1 reference

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18 January 2020

author name string

Yvette Drew

1

1 reference

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18 January 2020

Evan A Mulligan

2

1 reference

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18 January 2020

Wan-Tse Vong

3

1 reference

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18 January 2020

Huw D Thomas

4

1 reference

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18 January 2020

Samra Kahn

5

1 reference

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18 January 2020

Suzanne Kyle

6

1 reference

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18 January 2020

Asima Mukhopadhyay

7

1 reference

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18 January 2020

Gerrit Los

8

1 reference

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18 January 2020

Elizabeth R Plummer

10

1 reference

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18 January 2020

Richard J Edmondson

11

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18 January 2020

language of work or name

English

0 references

publication date

23 December 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21183737%20AND%20SRC:MED&resulttype=core&format=json

Journal of the National Cancer Institute

18 January 2020

published in

1 reference

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18 January 2020

volume

103

1 reference

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18 January 2020

issue

4

1 reference

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18 January 2020

page(s)

334-346

1 reference

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Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2

18 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Poly(ADP-ribose) polymerase-1 activation during DNA damage and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

DNA double-strand break repair: from mechanistic understanding to cancer treatment

21 January 2018

1 reference

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The concept of synthetic lethality in the context of anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Triple-negative breast cancer: therapeutic options

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

BRCA1 dysfunction in sporadic basal-like breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Hallmarks of 'BRCAness' in sporadic cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

The inhibition and treatment of breast cancer with poly (ADP-ribose) polymerase (PARP-1) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Absence of specific cell killing of the BRCA2-deficient human cancer cell line CAPAN1 by poly(ADP-ribose) polymerase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

New colorimetric cytotoxicity assay for anticancer-drug screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Resistance to therapy caused by intragenic deletion in BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Reduced ligation during DNA base excision repair supported by BRCA2 mutant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Lifespan, age changes and tumour incidence in an ageing C57BL mouse colony

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJQ509