(Q40674165)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12556458%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

title

gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta (English)

1 reference

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17 December 2019

2

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17 December 2019

Stefan F Lichtenthaler

3

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17 December 2019

Tobias Hartmann

6

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17 December 2019

author name string

Heike S Grimm

1

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17 December 2019

Mark S Shearman

4

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17 December 2019

Konrad Beyreuther

5

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17 December 2019

language of work or name

English

0 references

publication date

29 January 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12556458%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

17 December 2019

published in

1 reference

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17 December 2019

volume

278

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17 December 2019

issue

15

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17 December 2019

page(s)

13077-13085

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12556458%20AND%20SRC:MED&resulttype=core&format=json

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

17 December 2019

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21 January 2018

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Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

21 January 2018

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21 January 2018

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21 January 2018

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Consistent immunohistochemical detection of intracellular beta-amyloid42 in pyramidal neurons of Alzheimer's disease entorhinal cortex

21 January 2018

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Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice.

21 January 2018

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Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

21 January 2018

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Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein

21 January 2018

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Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein.

21 January 2018

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Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

21 January 2018

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Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

21 January 2018

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Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

21 January 2018

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Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide

21 January 2018

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Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture

21 January 2018

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Mutant presenilin 1 increases the levels of Alzheimer amyloid beta-peptide Abeta42 in late compartments of the constitutive secretory pathway.

21 January 2018

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Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

21 January 2018

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Presenilins are not required for A beta 42 production in the early secretory pathway.

21 January 2018

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

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Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

21 January 2018

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Presenilin 2 expression in neuronal cells: induction during differentiation of embryonic carcinoma cells.

21 January 2018

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Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay.

21 January 2018

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Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

21 January 2018

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21 January 2018

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Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

21 January 2018

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Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity

21 January 2018

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The TGN38 glycoprotein contains two non-overlapping signals that mediate localization to the trans-Golgi network

21 January 2018

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A microtubule-binding protein associated with membranes of the Golgi apparatus

21 January 2018

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A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein beta-adaptin.

21 January 2018

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Functional cooperation of two independent targeting domains in syntaxin 6 is required for its efficient localization in the trans-golgi network of 3T3L1 adipocytes

21 January 2018

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Beta-amyloid precursor protein cleavage by a membrane-bound protease

21 January 2018

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Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway

21 January 2018

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The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain

21 January 2018

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The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted

21 January 2018

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PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

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Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

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Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis

21 January 2018

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Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons

21 January 2018

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Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells

21 January 2018

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Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides

21 January 2018

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Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

21 January 2018

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Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

21 January 2018

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Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

21 January 2018

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Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

21 January 2018

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Alzheimer's disease-associated presenilin 1 in neuronal cells: Evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment

21 January 2018

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Intracellular site of gamma-secretase cleavage for Abeta42 generation in neuro 2a cells harbouring a presenilin 1 mutation

21 January 2018

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A novel substrate for analyzing Alzheimer's disease gamma-secretase

21 January 2018

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Mutations in the transmembrane domain of APP altering gamma-secretase specificity

21 January 2018

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Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

21 January 2018

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Differential effects of the swedish mutant amyloid precursor protein on beta-amyloid accumulation and secretion in neurons and nonneuronal cells

21 January 2018

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Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells

21 January 2018

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Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that int

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M210380200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12556458%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

1 reference