(Q40722638)

23 September 2017

title

Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin (English)

1 reference

23 September 2017

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4

C Ronald Kahn

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23 September 2017

2

Kohjiro Ueki

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23 September 2017

Yu-Hua Tseng

1

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23 September 2017

Kristina M Kriauciunas

series ordinal

3

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23 September 2017

language of work or name

English

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publication date

24 June 2002

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Journal of Biological Chemistry

23 September 2017

published in

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23 September 2017

volume

277

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23 September 2017

issue

35

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23 September 2017

page(s)

31601-31611

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Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

23 September 2017

cites work

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Disruption of IRS-2 causes type 2 diabetes in mice

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Insulin receptor substrate 3 is not essential for growth or glucose homeostasis.

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Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes

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Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes

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Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling

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Biochemical pathways of caspase activation during apoptosis

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Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

21 January 2018

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Transient activation of Jun N-terminal kinases and protection from apoptosis by the insulin-like growth factor I receptor can be suppressed by dicumarol

21 January 2018

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Insulin-like growth factor-I (IGF-I) receptor activation rescues UV-damaged cells through a p38 signaling pathway. Potential role of the IGF-I receptor in DNA repair

21 January 2018

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Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis

21 January 2018

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Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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Insulin-like growth factor-I induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein.

21 January 2018

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Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

21 January 2018

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

21 January 2018

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Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

21 January 2018

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Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis

21 January 2018

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Mechanism of activation and function of protein kinase B.

21 January 2018

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21 January 2018

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Insulin-like growth factor I-mediated activation of the transcription factor cAMP response element-binding protein in PC12 cells. Involvement of p38 mitogen-activated protein kinase-mediated pathway.

21 January 2018

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Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

21 January 2018

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Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR

21 January 2018

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Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

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Negative regulation of the forkhead transcription factor FKHR by Akt.

21 January 2018

1 reference

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

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The pleckstrin homology and phosphotyrosine binding domains of insulin receptor substrate 1 mediate inhibition of apoptosis by insulin

21 January 2018

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IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis

21 January 2018

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Brown adipose tissue thermogenesis during aging and senescence

21 January 2018

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A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family

21 January 2018

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Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I.

21 January 2018

1 reference

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The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

21 January 2018

1 reference

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Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

21 January 2018

1 reference

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Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons

21 January 2018

1 reference

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Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202932200

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

21 January 2018

1 reference

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Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

21 January 2018

1 reference

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Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202932200

Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation.

21 January 2018

1 reference

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The cell survival signal Akt is differentially activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells

21 January 2018

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Novel signaling pathway through the beta-adrenergic receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202932200

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202932200

21 January 2018

Identifiers

DOI

10.1074/JBC.M202932200

1 reference

23 September 2017

1 reference