(Q40727772)

23 September 2017

title

Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450. (English)

1 reference

23 September 2017

Remo Amherd

3

2 references

author name string

Christoph Handschin

1

1 reference

23 September 2017

Michael Podvinec

2

1 reference

23 September 2017

Remo Amherd

3

1 reference

23 September 2017

Renate Looser

4

1 reference

23 September 2017

Jean-Claude Ourlin

5

1 reference

23 September 2017

Urs A Meyer

6

1 reference

23 September 2017

language of work or name

English

0 references

publication date

3 June 2002

1 reference

Journal of Biological Chemistry

23 September 2017

number of pages

7

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

23 September 2017

volume

277

1 reference

23 September 2017

issue

33

1 reference

23 September 2017

page(s)

29561-29567

1 reference

Phenobarbital induction of cytochrome P-450 gene expression

23 September 2017

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1 reference

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21 January 2018

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P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

21 January 2018

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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

21 January 2018

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Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

21 January 2018

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CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

21 January 2018

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Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

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The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

21 January 2018

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Humanized xenobiotic response in mice expressing nuclear receptor SXR.

21 January 2018

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

21 January 2018

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A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line.

21 January 2018

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Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans

21 January 2018

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An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

21 January 2018

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Regulation of phenobarbital-inducible cytochrome P450 2B1/2 mRNA by lovastatin and oxysterols in primary cultures of adult rat hepatocytes

21 January 2018

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A Link between cholesterol levels and phenobarbital induction of cytochromes P450.

21 January 2018

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The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

21 January 2018

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The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism

21 January 2018

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Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate

21 January 2018

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The RXR heterodimers and orphan receptors

21 January 2018

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6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes

21 January 2018

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Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5beta-cholestane-3alpha,7alpha,12alpha-triol in human liver microsomes

21 January 2018

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Selective activation of liver X receptor alpha by 6alpha-hydroxy bile acids and analogs

21 January 2018

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The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

21 January 2018

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Nuclear receptors and lipid physiology: opening the X-files

21 January 2018

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Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).

21 January 2018

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Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

21 January 2018

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The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

21 January 2018

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The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

21 January 2018

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Effect of Antiepileptic drugs on plasma lipoprotein (a) and other lipid levels in childhood

21 January 2018

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Changes in serum lipids and lipoproteins in epileptic children treated with anticonvulsants.

21 January 2018

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Hyperlipidemia associated with HIV protease inhibitor use: pathophysiology, prevalence, risk factors and treatment

21 January 2018

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Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR.

21 January 2018

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Identification of bile acids in the serum and urine in cholestasis. Evidence for 6alpha-hydroxylation of bile acids in man

21 January 2018

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"Don't know much bile-ology"

21 January 2018

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Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols

21 January 2018

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Orphan nuclear receptors--new ligands and new possibilities.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M202739200

Molecular mechanisms of cytochrome P-450 induction by xenobiotics: An expanded role for nuclear hormone receptors.

21 January 2018

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Regulation of rat hepatic cytochrome P450 expression by sterol biosynthesis inhibition: inhibitors of squalene synthase are potent inducers of CYP2B expression in primary cultured rat hepatocytes and rat liver

21 January 2018

1 reference

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Negative regulation by dexamethasone of fluvastatin-inducible CYP2B expression in primary cultures of rat hepatocytes: role of CYP3A

21 January 2018

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Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei

21 January 2018

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Hepatic levels of bile acids in end-stage chronic cholestatic liver disease

21 January 2018

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Influence of cholesterol and protein diet on liver cytochrome P-450-dependent monooxygenase system in rats

21 January 2018

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Modulations in hepatic branch-point enzymes involved in isoprenoid biosynthesis upon dietary and drug treatments of rats

21 January 2018

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Cytochrome P450 2B enzyme (CYP2B) induction defect following phenobarbital treatment in the fa/fa Zucker rat: molecular characterization

21 January 2018

1 reference

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Effects of long-term treatment with antiepileptic drugs on serum lipid levels in children with epilepsy

21 January 2018

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Elevated plasma concentrations of lipoprotein(a) in medicated epileptic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202739200

Therapeutic use of phenobarbital in intrahepatic cholestasis. Inductions in bile acid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202739200

Stimulation of bile acid 6 alpha-hydroxylation by rifampin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202739200

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202739200

21 January 2018

Identifiers

DOI

10.1074/JBC.M202739200

1 reference

23 September 2017

1 reference