(Q40736222)

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Multiple lysine mutations in the C-terminus of p53 make it resistant to degradation mediated by MDM2 but not by human papillomavirus E6 and induce growth inhibition in MDM2-overexpressing cells

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Europe PubMed Central

23 September 2017

Multiple lysine mutations in the C-terminus of p53 make it resistant to degradation mediated by MDM2 but not by human papillomavirus E6 and induce growth inhibition in MDM2-overexpressing cells (English)

1 reference

Europe PubMed Central

23 September 2017

1 reference

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Seiichi Nakamura

1

1 reference

Europe PubMed Central

23 September 2017

Jack A Roth

2

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Europe PubMed Central

23 September 2017

Tapas Mukhopadhyay

3

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Europe PubMed Central

23 September 2017

language of work or name

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1 April 2002

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Europe PubMed Central

23 September 2017

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Europe PubMed Central

23 September 2017

21

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Europe PubMed Central

23 September 2017

2605-2610

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Europe PubMed Central

23 September 2017

16

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Europe PubMed Central

23 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1205343

0 references

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

Regulation of p53 stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

Functions of the MDM2 oncoprotein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

Mdm2 association with p53 targets its ubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

JNK targets p53 ubiquitination and degradation in nonstressed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

Regulation of Mdm2-directed degradation by the C terminus of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

Keeping an old friend under control: regulation of p53 stability.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

Twenty years of p53 research: structural and functional aspects of the p53 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

Mdm-2: "big brother" of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

Regulation of the p53 tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

Introduction: p53--the first twenty years

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

21 January 2018

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

7 January 2021

based on heuristic

inferred from DOI database lookup

Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205343

7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1038/SJ.ONC.1205343

1 reference

Europe PubMed Central

23 September 2017

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1 reference

Europe PubMed Central

23 September 2017

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